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Memory and naïve B-cell subsets in patients with multiple sclerosis

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Title: Memory and naïve B-cell subsets in patients with multiple sclerosis
Authors: Niino, Masaaki Browse this author
Hirotani, Makoto Browse this author
Miyazaki, Yusei Browse this author
Sasaki, Hidenao Browse this author
Keywords: Multiple sclerosis
Memory B cell
Naïve B cell
Cluster of differentiation
Issue Date: 16-Oct-2009
Publisher: Elsevier Ireland Ltd.
Journal Title: Neuroscience Letters
Volume: 464
Issue: 1
Start Page: 74
End Page: 78
Publisher DOI: 10.1016/j.neulet.2009.08.010
PMID: 19666086
Abstract: Memory and naïve B cells are considered to play distinct roles in immune regulation. However, the roles of memory and naïve B-cell subsets in multiple sclerosis (MS) have not yet been elucidated. In this study, we examined whether memory and naïve B-cell subsets differ between patients with MS and healthy subjects and whether interferon beta (IFNβ)-1b can affect these subsets in patients with MS. We also studied these subsets in relapsing and remitting stages of MS. Subjects included 31 patients with relapsing-remitting MS in the remitting stage, of which 15 were treated with IFNβ-1b and 16 were not treated, and 22 healthy control subjects. For 11 of the 16 untreated patients, blood samples were also obtained in the relapsing stage. Expression of CD5, CD80, CD86, CCR5, CXCR3, CD11a, and CD49d in memory and naïve B cells in blood samples was examined by flow cytometry. The percentages of CD86+ cells and CCR5+ cells in the naïve B-cell subset were significantly higher in untreated patients than in control subjects or IFNβ-treated patients. In patients with MS, the percentages of CD86+ cells and CCR5+ cells in the naïve B-cell subset and the percentage of CD5+ cells in the memory B-cell subset were significantly greater in the remitting stage than in the relapsing stage. These results indicate that memory and naïve B-cell subsets, especially CD86+ naïve B cells, CCR5+ naïve B cells, and CD5+ memory B cells, might be useful in the study of the pathogenesis of and therapy for MS.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 新野 正明

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