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Inhibitory Activity of (E)-5-(2-Bromovinyl)-2'-Deoxyuridine on the Salmonid Herpesviruses, Oncorhynchus masou Virus (OMV) and Herpesvirus salmonis

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Title: Inhibitory Activity of (E)-5-(2-Bromovinyl)-2'-Deoxyuridine on the Salmonid Herpesviruses, Oncorhynchus masou Virus (OMV) and Herpesvirus salmonis
Authors: Kimura, Takahisa Browse this author →KAKEN DB
Nishizawa, Toyohiko Browse this author →KAKEN DB
Yoshimizu, Mamoru Browse this author →KAKEN DB
De Clercq, Erik Browse this author
Issue Date: 1988
Publisher: Center for Academic Publications Japan
Journal Title: Microbiology and Immunology
Volume: 32
Issue: 1
Start Page: 57
End Page: 65
Abstract: The highly potent and selective anti-herpesvirus agent, (E)-5-(2-bromovinyl)-2'deoxyuridine (BVdU), was examined for its inhibitory effect on the salmonid herpesviruses Oncorhynchus masou virus (OMV) and Herpesvirus salmonis (H. salmonis). Minimum inhibitory concentrations (MIC) of BVdU for OMV and H. salmonis were 1.25 and 3.0 μg/ml, respectively; these values were equal to or higher than those obtained for acyclovir or cytarabin. OMV DNA polymerase activity was reduced in a dose-dependent fashion by BVdU 5'-triphosphate (BVdUTP) within the concentration range of 3 to 30 μm. However, BVdUTP could also be substituted for the natural substrate, TTP, in the OMV DNA polymerase assay. It is postulated that the inhibitory action of BVdU on the salmonid herpesviruses is more or less similar to that on other herpesviruses and resides with respect to the inhibition of the virus DNA polymerase activity as well as incorporation of BVdU into the viral DNA.
Type: article
URI: http://hdl.handle.net/2115/39476
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 吉水 守

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