| Title: | The influence of hepatitis B DNA level and antiviral therapy on recurrence after initial curative treatment in patients with hepatocellular carcinoma |
| Authors: | Chuma, Makoto Browse this author →KAKEN DB |
| Hige, Shuhei Browse this author →KAKEN DB |
| Kamiyama, Toshiya Browse this author |
| Meguro, Takashi Browse this author |
| Nagasaka, Atsushi Browse this author |
| Nakanishi, Kazuaki Browse this author |
| Yamamoto, Yoshiya Browse this author |
| Nakanishi, Mitsuru Browse this author |
| Kohara, Toshihisa Browse this author |
| Sho, Takuya Browse this author |
| Yamamoto, Keiko Browse this author |
| Horimoto, Hiromasa Browse this author |
| Kobayashi, Tomoe Browse this author |
| Yokoo, Hideki Browse this author |
| Matsushita, Michiaki Browse this author →KAKEN DB |
| Todo, Satoru Browse this author |
| Asaka, Masahiro Browse this author |
| Keywords: | Hepatocellular carcinoma |
| Hepatitis B virus |
| Recurrence |
| Antiviral therapy |
| Issue Date: | Sep-2009 |
| Publisher: | Springer Japan |
| Journal Title: | Journal of Gastroenterology |
| Volume: | 44 |
| Issue: | 9 |
| Start Page: | 991 |
| End Page: | 999 |
| Publisher DOI: | 10.1007/s00535-009-0093-z |
| PMID: | 19554391 |
| Abstract: | Background. Prediction and prevention of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) recurrence is an important clinical issue. We investigated whether HBV DNA level and antiviral therapy are associated with HCC recurrence. Methods. This retrospective study involved 103 patients who underwent hepatic resection or radiofrequency ablation for initial HCC. Patients were divided into four groups. Thirty had high serum HBV DNA levels (>4 log10 copies/mL) and had not received antiviral therapy (high virus group; HVG). Thirty-four had low HBV DNA levels (≤4 log10 copies/mL) and had not received antiviral therapy (low virus group; LVG). Twenty received antiviral therapy after HCC developed (therapeutic group A, TG-A). Nineteen received antiviral therapy before HCC developed (therapeutic group B, TG-B). Results. Cumulative HCC recurrence rates at 3 years in the HVG, LVG, TG-B, and TG-A were 71.1%, 42.2%, 42.3%, and 52.0%, respectively. Recurrence rates differed significantly between the HVG and LVG (P = 0.016) and between the HVG and TG-B (P = 0.008). Recurrence rate in the TG-A was marginally lower than in the HVG (P = 0.10). On multivariate analysis, high serum hepatitis B virus DNA levels (hazard ratio: HR, 2.67; 95% CI, 1.31-5.47; P = 0.007) and absence of antiviral therapy (HR, 2.57; 95% CI, 1.34-4.94; P = 0.005) were independent risk factors for hepatocellular carcinoma recurrence. Conclusion. HBV DNA level and antiviral therapy are associated with HCC recurrence. For patients with high HBV DNA levels, antiviral therapy before the development of HCC is important for prevention of recurrence. |
| Rights: | The original publication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/39478 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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