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Functional analysis of Foxp3 and CTLA-4 expressing HTLV-1-infected cells in a rat model

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タイトル: Functional analysis of Foxp3 and CTLA-4 expressing HTLV-1-infected cells in a rat model
著者: Takayanagi, Ryo 著作を一覧する
Ohashi, Takashi 著作を一覧する
Shida, Hisatoshi 著作を一覧する
キーワード: HTLV-1
Animal model
発行日: 2009年10月
出版者: Elsevier Masson SAS
誌名: Microbes and Infection
巻: 11
号: 12
開始ページ: 964
終了ページ: 972
出版社 DOI: 10.1016/j.micinf.2009.06.007
抄録: Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia (ATL). Some ATL cells express Foxp3, which is known as regulatory T cell (Treg cell) specific transcription factor. It is suggested that Treg cell like suppressive activity of Foxp3 expressing ATL cells is associated to ATL development and related immunodeficiency. To develop an HTLV-I model system that enables to investigate the association of Treg function in ATL progression, we examined the expression of Foxp3 and CTLA-4, Treg cell-associated factor, in established HTLV-1-infected rat cell lines and their regulatory function. We found the expression of Foxp3 in 10 of 22 and CTLA-4 in 10 of 19 HTLV-1-infected rat cell lines. Moreover, some of the Foxp3 and/or CTLA-4 expressing cell lines suppressed proliferation of naïve T cells that were stimulated with anti-CD3 antibody. Particularly all Foxp3+ CTLA-4+ cells showed the suppressive activity. Our data suggest the usefulness of our rat model systems for further analysis of the role of Treg cell-associated factors on the development of ATL and related immunodeficiency in vivo.
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 志田 壽利


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