ZNRF1 interacts with tubulin and regulates cell morphogenesis


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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/39666

Title:	ZNRF1 interacts with tubulin and regulates cell morphogenesis
Authors:	Yoshida, Koichi Browse this author
	Watanabe, Masashi Browse this author
	Hatakeyama, Shigetsugu Browse this author →KAKEN DB
Keywords:	ZNRF1
	Tubulin
	Ubiquitin
	RING finger
	Zinc finger
Issue Date:	20-Nov-2009
Publisher:	Elsevier Inc.
Journal Title:	Biochemical and Biophysical Research Communications
Volume:	389
Issue:	3
Start Page:	506
End Page:	511
Publisher DOI:	10.1016/j.bbrc.2009.09.011
PMID:	19737534
Abstract:	The ubiquitin-proteasome system has been implicated in neuronal degeneration and regeneration. We demonstrated that overexpression of ZNRF1, which has been identified as a crucial molecule in nerve regeneration, causes morphological changes such as neurite-like elongation. Molecular dissections showed that both the RING finger domain and zinc finger domain are required for morphological changes. Furthermore, we identified β-tubulin type 2 (Tubb2) as a ZNRF1-binding protein by yeast two-hybrid screening. In vivo binding assay showed that ZNRF1 interacts with Tubb2 and immunofluorescent staining suggests that ZNRF1 is colocalized with Tubb2. These results suggest that ZNRF1 mediates regulation of neuritogenesis via interaction with tubulin.
Type:	article (author version)
URI:	http://hdl.handle.net/2115/39666
Appears in Collections:	医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 畠山鎮次

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