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ZNRF1 interacts with tubulin and regulates cell morphogenesis

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タイトル: ZNRF1 interacts with tubulin and regulates cell morphogenesis
著者: Yoshida, Koichi 著作を一覧する
Watanabe, Masashi 著作を一覧する
Hatakeyama, Shigetsugu 著作を一覧する
キーワード: ZNRF1
Tubulin
Ubiquitin
RING finger
Zinc finger
発行日: 2009年11月20日
出版者: Elsevier Inc.
誌名: Biochemical and Biophysical Research Communications
巻: 389
号: 3
開始ページ: 506
終了ページ: 511
出版社 DOI: 10.1016/j.bbrc.2009.09.011
抄録: The ubiquitin-proteasome system has been implicated in neuronal degeneration and regeneration. We demonstrated that overexpression of ZNRF1, which has been identified as a crucial molecule in nerve regeneration, causes morphological changes such as neurite-like elongation. Molecular dissections showed that both the RING finger domain and zinc finger domain are required for morphological changes. Furthermore, we identified β-tubulin type 2 (Tubb2) as a ZNRF1-binding protein by yeast two-hybrid screening. In vivo binding assay showed that ZNRF1 interacts with Tubb2 and immunofluorescent staining suggests that ZNRF1 is colocalized with Tubb2. These results suggest that ZNRF1 mediates regulation of neuritogenesis via interaction with tubulin.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/39666
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 畠山 鎮次

 

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