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Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight
Title: | Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight |
Authors: | Konishi, Kanae Browse this author | Sasaki, Seiko Browse this author →KAKEN DB | Kato, Shizue Browse this author | Ban, Susumu Browse this author →KAKEN DB | Washino, Noriaki Browse this author | Kajiwara, Jumboku Browse this author | Todaka, Takashi Browse this author | Hirakawa, Hironori Browse this author | Hori, Tsuguhide Browse this author | Yasutake, Daisuke Browse this author | Kishi, Reiko Browse this author →KAKEN DB |
Keywords: | Birth weight | Fetal growth | Dioxin | Maternal blood | Prenatal exposure |
Issue Date: | Oct-2009 |
Publisher: | Elsevier Inc. |
Journal Title: | Environmental Research |
Volume: | 109 |
Issue: | 7 |
Start Page: | 906 |
End Page: | 913 |
Publisher DOI: | 10.1016/j.envres.2009.07.010 |
PMID: | 19683226 |
Abstract: | Several human studies have shown that low-level exposure to environmental contaminants, such as polychlorinated biphenyls (PCBs) and organochlorine pesticides, negatively influences birth outcomes. However, the effects of low-level exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) on birth outcomes have not been clarified in human studies. A prospective cohort study was established to investigate the possible adverse effects of PCDDs/PCDFs and DL-PCBs on fetal growth and neurodevelopment. We recruited 514 pregnant women between July 2002 and October 2005 in Sapporo, Japan. We measured 29 congener levels of PCDDs/PCDFs and DL-PCBs in maternal blood. Using multiple liner regression analysis of the association between birth weight and the levels of PCDDs/PCDFs and DL-PCBs with full adjustments for potential confounders, a significant adverse effect was observed regarding total PCDDs toxic equivalents (TEQ) levels (adjusted β = -231.5 g, 95% Cl: -417.4 to -45.6) and total PCDFs TEQ levels (adjusted β = -258.8 g, 95% Cl: -445.7 to -71.8). Among male infants, significant adverse associations with birth weight were found for total PCDDs TEQ level, total PCDDs/PCDFs TEQ level, and total TEQ level. However, among female infants, these significant adverse associations were not found. With regard to individual congeners of PCDDs/PCDFs and DL-PCBs, we found significantly negative association with the levels of 2,3,4,7,8-PeCDF (adjusted β = -24.5 g, 95% Cl: -387.4 to -61.5). Our findings suggest that prenatal low-level exposure to PCDDs and PCDFs, especially 2,3,4,7,8-PeCDF, may accumulate in the placenta and retard important placental functions, which result in lower birth weight. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/39727 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 岸 玲子
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