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Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/39727

Title: Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight
Authors: Konishi, Kanae Browse this author
Sasaki, Seiko Browse this author →KAKEN DB
Kato, Shizue Browse this author
Ban, Susumu Browse this author →KAKEN DB
Washino, Noriaki Browse this author
Kajiwara, Jumboku Browse this author
Todaka, Takashi Browse this author
Hirakawa, Hironori Browse this author
Hori, Tsuguhide Browse this author
Yasutake, Daisuke Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Birth weight
Fetal growth
Dioxin
Maternal blood
Prenatal exposure
Issue Date: Oct-2009
Publisher: Elsevier Inc.
Journal Title: Environmental Research
Volume: 109
Issue: 7
Start Page: 906
End Page: 913
Publisher DOI: 10.1016/j.envres.2009.07.010
PMID: 19683226
Abstract: Several human studies have shown that low-level exposure to environmental contaminants, such as polychlorinated biphenyls (PCBs) and organochlorine pesticides, negatively influences birth outcomes. However, the effects of low-level exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) on birth outcomes have not been clarified in human studies. A prospective cohort study was established to investigate the possible adverse effects of PCDDs/PCDFs and DL-PCBs on fetal growth and neurodevelopment. We recruited 514 pregnant women between July 2002 and October 2005 in Sapporo, Japan. We measured 29 congener levels of PCDDs/PCDFs and DL-PCBs in maternal blood. Using multiple liner regression analysis of the association between birth weight and the levels of PCDDs/PCDFs and DL-PCBs with full adjustments for potential confounders, a significant adverse effect was observed regarding total PCDDs toxic equivalents (TEQ) levels (adjusted β = -231.5 g, 95% Cl: -417.4 to -45.6) and total PCDFs TEQ levels (adjusted β = -258.8 g, 95% Cl: -445.7 to -71.8). Among male infants, significant adverse associations with birth weight were found for total PCDDs TEQ level, total PCDDs/PCDFs TEQ level, and total TEQ level. However, among female infants, these significant adverse associations were not found. With regard to individual congeners of PCDDs/PCDFs and DL-PCBs, we found significantly negative association with the levels of 2,3,4,7,8-PeCDF (adjusted β = -24.5 g, 95% Cl: -387.4 to -61.5). Our findings suggest that prenatal low-level exposure to PCDDs and PCDFs, especially 2,3,4,7,8-PeCDF, may accumulate in the placenta and retard important placental functions, which result in lower birth weight.
Type: article (author version)
URI: http://hdl.handle.net/2115/39727
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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