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Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

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タイトル: Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight
著者: Konishi, Kanae 著作を一覧する
Sasaki, Seiko 著作を一覧する
Kato, Shizue 著作を一覧する
Ban, Susumu 著作を一覧する
Washino, Noriaki 著作を一覧する
Kajiwara, Jumboku 著作を一覧する
Todaka, Takashi 著作を一覧する
Hirakawa, Hironori 著作を一覧する
Hori, Tsuguhide 著作を一覧する
Yasutake, Daisuke 著作を一覧する
Kishi, Reiko 著作を一覧する
キーワード: Birth weight
Fetal growth
Maternal blood
Prenatal exposure
発行日: 2009年10月
出版者: Elsevier Inc.
誌名: Environmental Research
巻: 109
号: 7
開始ページ: 906
終了ページ: 913
出版社 DOI: 10.1016/j.envres.2009.07.010
抄録: Several human studies have shown that low-level exposure to environmental contaminants, such as polychlorinated biphenyls (PCBs) and organochlorine pesticides, negatively influences birth outcomes. However, the effects of low-level exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) on birth outcomes have not been clarified in human studies. A prospective cohort study was established to investigate the possible adverse effects of PCDDs/PCDFs and DL-PCBs on fetal growth and neurodevelopment. We recruited 514 pregnant women between July 2002 and October 2005 in Sapporo, Japan. We measured 29 congener levels of PCDDs/PCDFs and DL-PCBs in maternal blood. Using multiple liner regression analysis of the association between birth weight and the levels of PCDDs/PCDFs and DL-PCBs with full adjustments for potential confounders, a significant adverse effect was observed regarding total PCDDs toxic equivalents (TEQ) levels (adjusted β = -231.5 g, 95% Cl: -417.4 to -45.6) and total PCDFs TEQ levels (adjusted β = -258.8 g, 95% Cl: -445.7 to -71.8). Among male infants, significant adverse associations with birth weight were found for total PCDDs TEQ level, total PCDDs/PCDFs TEQ level, and total TEQ level. However, among female infants, these significant adverse associations were not found. With regard to individual congeners of PCDDs/PCDFs and DL-PCBs, we found significantly negative association with the levels of 2,3,4,7,8-PeCDF (adjusted β = -24.5 g, 95% Cl: -387.4 to -61.5). Our findings suggest that prenatal low-level exposure to PCDDs and PCDFs, especially 2,3,4,7,8-PeCDF, may accumulate in the placenta and retard important placental functions, which result in lower birth weight.
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 岸 玲子


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