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Volume 57, Number 3 >

Proinsulin C-peptide induces c-Jun N-terminal kinase 1 expression in LEII mouse lung capillary endothelial cells

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.57.3.163

Title: Proinsulin C-peptide induces c-Jun N-terminal kinase 1 expression in LEII mouse lung capillary endothelial cells
Authors: Furuya, Daniela Tomie Browse this author
Ishii, Tatsuya Browse this author
Kamikawa, Akihiro Browse this author
Shimada, Kohei Browse this author
Machado, Ubiratan Fabres Browse this author
Saito, Masayuki Browse this author
Kimura, Kazuhiro Browse this author →KAKEN DB
Keywords: C-peptide
diabetes mellitus
JNK
Issue Date: Nov-2009
Publisher: Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 57
Issue: 3
Start Page: 163
End Page: 167
Abstract: To characterize the roles of C-peptide in vascular homeostatic processes, we examined the genes regulated by C-peptide in LEII mouse lung microvascular endothelial cells. Treatment of the cells with C-peptide increased the expression of c-Jun N-terminal kinase 1 (JNK1) mRNA dose-dependently, accompanied by an increase in JNK1 protein content. Prior treatment of the cells with PD98059, an ERK kinase inhibitor or SB203580, a p38MAPK inhibitor, abrogated the C-peptide-elicited JNK1 mRNA expression. These results indicate that C-peptide increases JNK1 protein levels, possibly through ERK- and p38MAPK-dependent activation of JNK gene transcription.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/39937
Appears in Collections:Japanese Journal of Veterinary Research > Volume 57, Number 3

Submitter: 獣医学部図書室

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