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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >
Antigenic structure of the hemagglutinin of H9N2 influenza viruses.
| Title: | Antigenic structure of the hemagglutinin of H9N2 influenza viruses. |
| Authors: | Okamatsu, Masatoshi Browse this author →KAKEN DB | | Sakoda, Yoshihiro Browse this author →KAKEN DB | | Kishida, Noriko Browse this author →KAKEN DB | | Isoda, Norikazu Browse this author | | Kida, Hiroshi Browse this author →KAKEN DB |
| Keywords: | H9N2 | | hemagglutinin | | influenza virus | | monoclonal antibody |
| Issue Date: | Dec-2008 |
| Publisher: | Springer Wien |
| Journal Title: | Archives of Virology |
| Volume: | 153 |
| Issue: | 12 |
| Start Page: | 2189 |
| End Page: | 2195 |
| Publisher DOI: | 10.1007/s00705-008-0243-2 |
| PMID: | 18989614 |
| Abstract: | The hemagglutinins (HAs) of H9 influenza viruses isolated from birds and mammals of different species were antigenically and genetically analyzed. Antigenic variants were selected from A/swine/Hong Kong/10/98 (H9N2) and A/duck/Hokkaido/13/00 (H9N2) in the presence of monoclonal antibodies (MAbs), respectively. Based on the reactivity patterns of these mutants with a panel of MAbs, at least 5 non-overlapping antigenic sites were defined using 8 MAbs which recognized 7 distinct epitopes on the H9 HA molecule. Based on the reactivity patterns with the panel of monoclonal antibodies, 21 H9N2 virus strains isolated from birds and mammals were divided into 7 antigenically distinct groups. The present findings indicate that it is important to monitor the antigenic variation in H9 influenza viruses. The panel of MAbs in the present study, thus, should be useful for detailed antigenic analysis of the H9 HAs for epidemiological studies, the selection of vaccine strains, and diagnosis. |
| Rights: | The original publication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/39950 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 迫田 義博
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