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Antigenic structure of the hemagglutinin of H9N2 influenza viruses.

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/39950

Title: Antigenic structure of the hemagglutinin of H9N2 influenza viruses.
Authors: Okamatsu, Masatoshi Browse this author →KAKEN DB
Sakoda, Yoshihiro Browse this author →KAKEN DB
Kishida, Noriko Browse this author →KAKEN DB
Isoda, Norikazu Browse this author
Kida, Hiroshi Browse this author →KAKEN DB
Keywords: H9N2
hemagglutinin
influenza virus
monoclonal antibody
Issue Date: Dec-2008
Publisher: Springer Wien
Journal Title: Archives of Virology
Volume: 153
Issue: 12
Start Page: 2189
End Page: 2195
Publisher DOI: 10.1007/s00705-008-0243-2
PMID: 18989614
Abstract: The hemagglutinins (HAs) of H9 influenza viruses isolated from birds and mammals of different species were antigenically and genetically analyzed. Antigenic variants were selected from A/swine/Hong Kong/10/98 (H9N2) and A/duck/Hokkaido/13/00 (H9N2) in the presence of monoclonal antibodies (MAbs), respectively. Based on the reactivity patterns of these mutants with a panel of MAbs, at least 5 non-overlapping antigenic sites were defined using 8 MAbs which recognized 7 distinct epitopes on the H9 HA molecule. Based on the reactivity patterns with the panel of monoclonal antibodies, 21 H9N2 virus strains isolated from birds and mammals were divided into 7 antigenically distinct groups. The present findings indicate that it is important to monitor the antigenic variation in H9 influenza viruses. The panel of MAbs in the present study, thus, should be useful for detailed antigenic analysis of the H9 HAs for epidemiological studies, the selection of vaccine strains, and diagnosis.
Rights: The original publication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/39950
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 迫田 義博

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