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The response of antithrombin III activity after supplementation decreases in proportion to the severity of sepsis and liver dysfunction

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Title: The response of antithrombin III activity after supplementation decreases in proportion to the severity of sepsis and liver dysfunction
Authors: Hayakawa, Mineji Browse this author →KAKEN DB
Sawamura, Atsushi Browse this author
Yanagida, Yuichiro Browse this author
Sugano, Masahiro Browse this author
Hoshino, Hirokatsu Browse this author
Gando, Satoshi Browse this author
Keywords: anticoagulation
capillary leak syndrome
disseminated intravascular coagulation
multiple organ dysfunction syndrome
pharmacokinetics
septic shock
systemic inflammatory response syndrome
Issue Date: Dec-2008
Publisher: Lippincott Williams & Wilkins
Journal Title: Shock
Volume: 30
Issue: 6
Start Page: 649
End Page: 652
Publisher DOI: 10.1097/SHK.0b013e318173e396
PMID: 18496242
Abstract: The decrease in the antithrombin III activity is thought to result from consumption by ongoing coagulation, degradation by neutrophil elastase, capillary leak syndrome, and impaired synthesis. A retrospective data analysis of patients with sepsis was conducted to investigate the response of antithrombin III activity after supplementation in patients with sepsis, and to determine what factors affect the response of antithrombin III activity. The study included 42 sepsis, 75 severe sepsis and 65 septic shock patients, who were administrated antithrombin III. Antithrombin III activity, platelet counts, coagulation and fibrinolytic markers were collected before administration and 24 hr after the supplementation. In the patients with septic shock, the response of antithrombin III activity after supplementation was 0.37 ± 1.21%/IU/kg body weight, which was significantly lower in comparison to those in the patients with sepsis (1.81 ± 1.75 ; P < 0.001) or severe sepsis (1.36 ± 1.65 ; P < 0.001). The patients with liver dysfunction had significantly lower response to antithrombin III activity than that of the patients without liver dysfunction (P < 0.0001). A stepwise multiple-linear regression analysis revealed that the severity of sepsis and liver function were independent predictors for the response to antithrombin III activity. These results suggest that the response to antithrombin III supplementation may be affected by both a systemic inflammation and impaired synthesis in patients with sepsis.
Rights: This is a non-final version of an article published in final form in Shock. 30(6):649-652, December 2008
Relation: http://www.shockjournal.com/
Type: article (author version)
URI: http://hdl.handle.net/2115/40198
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 早川 峰司

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