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Microwave Effect for Glycosylation Promoted by Solid Super Acid in Supercritical Carbon Dioxide
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| Title: | Microwave Effect for Glycosylation Promoted by Solid Super Acid in Supercritical Carbon Dioxide |
| Authors: | Hinou, Hiroshi Browse this author →KAKEN DB | | Saito, Naohiro Browse this author | | Ogawa, Masato Browse this author | | Maeda, Takahiko Browse this author | | Nishimura, Shin-Ichiro Browse this author →KAKEN DB |
| Keywords: | glycosylation | | microwave | | super solid acid | | supercritical carbon dioxide | | dielectric constant | | electric delocalization | | symmetric structure |
| Issue Date: | Dec-2009 |
| Publisher: | Molecular Diversity Preservation International (MDPI) |
| Journal Title: | International Journal of Molecular Sciences |
| Volume: | 10 |
| Issue: | 12 |
| Start Page: | 5285 |
| End Page: | 5295 |
| Publisher DOI: | 10.3390/ijms10125285 |
| Abstract: | The effects of microwave irradiation (2.45 GHz, 200 W) on glycosylation promoted by a solid super acid in supercritical carbon dioxide was investigated with particular attention paid to the structure of the acceptor substrate. Because of the symmetrical structure and high diffusive property of supercritical carbon dioxide, microwave irradiation did not alter the temperature of the reaction solution, but enhanced reaction yield when aliphatic acceptors are employed. Interestingly, the use of a phenolic acceptor under the same reaction conditions did not show these promoting effects due to microwave irradiation. In the case of aliphatic diol acceptors, the yield seemed to be dependent on the symmetrical properties of the acceptors. The results suggest that microwave irradiation do not affect the reactivity of the donor nor promoter independently. We conclude that the effect of acceptor structure on glycosylation yield is due to electric delocalization of hydroxyl group and dielectrically symmetric structure of whole molecule. |
| Rights: | http://creativecommons.org/licenses/by/3.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/42525 |
| Appears in Collections: | 生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 比能 洋
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