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Microwave Effect for Glycosylation Promoted by Solid Super Acid in Supercritical Carbon Dioxide

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Title: Microwave Effect for Glycosylation Promoted by Solid Super Acid in Supercritical Carbon Dioxide
Authors: Hinou, Hiroshi Browse this author →KAKEN DB
Saito, Naohiro Browse this author
Ogawa, Masato Browse this author
Maeda, Takahiko Browse this author
Nishimura, Shin-Ichiro Browse this author →KAKEN DB
Keywords: glycosylation
microwave
super solid acid
supercritical carbon dioxide
dielectric constant
electric delocalization
symmetric structure
Issue Date: Dec-2009
Publisher: Molecular Diversity Preservation International (MDPI)
Journal Title: International Journal of Molecular Sciences
Volume: 10
Issue: 12
Start Page: 5285
End Page: 5295
Publisher DOI: 10.3390/ijms10125285
Abstract: The effects of microwave irradiation (2.45 GHz, 200 W) on glycosylation promoted by a solid super acid in supercritical carbon dioxide was investigated with particular attention paid to the structure of the acceptor substrate. Because of the symmetrical structure and high diffusive property of supercritical carbon dioxide, microwave irradiation did not alter the temperature of the reaction solution, but enhanced reaction yield when aliphatic acceptors are employed. Interestingly, the use of a phenolic acceptor under the same reaction conditions did not show these promoting effects due to microwave irradiation. In the case of aliphatic diol acceptors, the yield seemed to be dependent on the symmetrical properties of the acceptors. The results suggest that microwave irradiation do not affect the reactivity of the donor nor promoter independently. We conclude that the effect of acceptor structure on glycosylation yield is due to electric delocalization of hydroxyl group and dielectrically symmetric structure of whole molecule.
Rights: http://creativecommons.org/licenses/by/3.0/
Type: article
URI: http://hdl.handle.net/2115/42525
Appears in Collections:生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 比能 洋

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