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TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells

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Title: TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells
Authors: Kikuchi, Misato Browse this author
Okumura, Fumihiko Browse this author
Tsukiyama, Tadasuke Browse this author
Watanabe, Masashi Browse this author
Miyajima, Naoto Browse this author
Tanaka, Junji Browse this author
Imamura, Masahiro Browse this author
Hatakeyama, Shigetsugu Browse this author →KAKEN DB
Keywords: TRIM24
Androgen receptor
Prostate cancer
BRD7
Issue Date: Dec-2009
Publisher: Elsevier B.V.
Journal Title: Biochimica et Biophysica Acta (BBA) : Molecular Cell Research
Volume: 1793
Issue: 12
Start Page: 1828
End Page: 1836
Publisher DOI: 10.1016/j.bbamcr.2009.11.001
PMID: 19909775
Abstract: The androgen receptor (AR) is a ligand-dependent transcription factor that belongs to the family of nuclear receptors, and its activity is regulated by numerous AR coregulators. AR plays an important role in prostate development and cancer. In this study, we found that TRIM24/transcriptional intermediary factor 1α (TIF1α), which is known as a ligand-dependent nuclear receptor co-regulator, interacts with AR and enhances transcriptional activity of AR by dihydrotestosterone in prostate cancer cells. We showed that TRIM24 functionally interacts with TIP60, which acts as a coactivator of AR and synergizes with TIP60 in the transactivation of AR. We also showed that TRIM24 binds to bromodomain containing 7 (BRD7), which can negatively regulate cell proliferation and growth. A luciferase assay indicated that BRD7 represses the AR transactivation activity upregulated by TRIM24. These findings indicate that TRIM24 regulates AR-mediated transcription in collaboration with TIP60 and BRD7.
Type: article (author version)
URI: http://hdl.handle.net/2115/42555
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 畠山 鎮次

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