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Dendritic cell-derived TNF-α is responsible for development of IL-10-producing CD4+ T cells

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Title: Dendritic cell-derived TNF-α is responsible for development of IL-10-producing CD4+ T cells
Authors: Hirata, Noriyuki Browse this author
Yanagawa, Yoshiki Browse this author
Satoh, Masashi Browse this author
Ogura, Hisako Browse this author
Ebihara, Takashi Browse this author
Noguchi, Masayuki Browse this author →KAKEN DB
Matsumoto, Machiko Browse this author
Togashi, Hiroko Browse this author
Seya, Tsukasa Browse this author
Onoé, Kazunori Browse this author
Iwabuchi, Kazuya Browse this author
Keywords: Dendritic cells
CD4+ T cells
TNF-α
IL-10
Antigen presentation
Issue Date: 2010
Publisher: Elsevier
Journal Title: Cellular Immunology
Volume: 261
Issue: 1
Start Page: 37
End Page: 41
Publisher DOI: 10.1016/j.cellimm.2009.10.009
PMID: 19931858
Abstract: Immature dendritic cells (DCs) appear to be involved in peripheral immune tolerance via induction of IL-10-producing CD4+ T cells. We examined the role of TNF-α in generation of the IL-10-producing CD4+ T cells by immature DCs. Immature bone marrow-derived DCs from wild type (WT) or TNF-α^[-/-] mice were cocultured with CD4+ T cells from OVA specific TCR transgenic mice (OT-II) in the presence of OVA_[323-339] peptide. The WT DCs efficiently induced the antigen-specific IL-10-producing CD4+ T cells, while the ability of the TNF-α^[-/-] DCs to induce these CD4+ T cells was considerably depressed. Addition of exogenous TNF-α recovered the impaired ability of the TNF-α^[-/-] DCs to induce IL-10-producing T cells. However, no difference in this ability was observed between TNF-α^[-/-] and WT DCs after their maturation by LPS. Thus, TNF-α appears to be critical for the generation of IL-10-producing CD4+ T cells during the antigen presentation by immature DCs.
Type: article (author version)
URI: http://hdl.handle.net/2115/42635
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 平田 徳幸

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