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Dendritic cell-derived TNF-α is responsible for development of IL-10-producing CD4+ T cells
Title: | Dendritic cell-derived TNF-α is responsible for development of IL-10-producing CD4+ T cells |
Authors: | Hirata, Noriyuki Browse this author | Yanagawa, Yoshiki Browse this author | Satoh, Masashi Browse this author | Ogura, Hisako Browse this author | Ebihara, Takashi Browse this author | Noguchi, Masayuki Browse this author →KAKEN DB | Matsumoto, Machiko Browse this author | Togashi, Hiroko Browse this author | Seya, Tsukasa Browse this author | Onoé, Kazunori Browse this author | Iwabuchi, Kazuya Browse this author |
Keywords: | Dendritic cells | CD4+ T cells | TNF-α | IL-10 | Antigen presentation |
Issue Date: | 2010 |
Publisher: | Elsevier |
Journal Title: | Cellular Immunology |
Volume: | 261 |
Issue: | 1 |
Start Page: | 37 |
End Page: | 41 |
Publisher DOI: | 10.1016/j.cellimm.2009.10.009 |
PMID: | 19931858 |
Abstract: | Immature dendritic cells (DCs) appear to be involved in peripheral immune tolerance via induction of IL-10-producing CD4+ T cells. We examined the role of TNF-α in generation of the IL-10-producing CD4+ T cells by immature DCs. Immature bone marrow-derived DCs from wild type (WT) or TNF-α^[-/-] mice were cocultured with CD4+ T cells from OVA specific TCR transgenic mice (OT-II) in the presence of OVA_[323-339] peptide. The WT DCs efficiently induced the antigen-specific IL-10-producing CD4+ T cells, while the ability of the TNF-α^[-/-] DCs to induce these CD4+ T cells was considerably depressed. Addition of exogenous TNF-α recovered the impaired ability of the TNF-α^[-/-] DCs to induce IL-10-producing T cells. However, no difference in this ability was observed between TNF-α^[-/-] and WT DCs after their maturation by LPS. Thus, TNF-α appears to be critical for the generation of IL-10-producing CD4+ T cells during the antigen presentation by immature DCs. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/42635 |
Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 平田 徳幸
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