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IL-6 and IFN-α from dsRNA-stimulated dendritic cells control expansion of regulatory T cells
Title: | IL-6 and IFN-α from dsRNA-stimulated dendritic cells control expansion of regulatory T cells |
Authors: | Kubota, Nobuhiko Browse this author | Ebihara, Takashi Browse this author | Matsumoto, Misako Browse this author | Gando, Satoshi Browse this author | Seya, Tsukasa Browse this author |
Keywords: | TICAM-1 (TRIF) | Interferon-alpha | IL-6 | Dendritic cells | Regulatory T cells (Treg) |
Issue Date: | 15-Jan-2010 |
Publisher: | Elsevier |
Journal Title: | Biochemical and Biophysical Research Communications |
Volume: | 391 |
Issue: | 3 |
Start Page: | 1421 |
End Page: | 1426 |
Publisher DOI: | 10.1016/j.bbrc.2009.12.081 |
PMID: | 20026056 |
Abstract: | Foxp3+CD4+ regulatory T cells (Treg) control not only autoinimunity but also the effective immune response against RNA virus infections, which produces virus-derived double-stranded RNA (dsRNA). To induce effective anti-viral immunity, it is a key issue to learn how Treg respond to dsRNA in vitro and in vivo. We here showed that synthetic dsRNA, polyI:C, caused peripheral expansion of functional Treg in a TICAM-1- and IL-6-dependent manner in vivo. PolyI:C did not expand Treg directly, but promoted the expansion of naturally occurring Treg indirectly through IL-6 produced from dendritic cells (DCs). In addition, the expansion of Treg by IL-6 was inhibited by IFN-α from polyI:C-stimulated DCs. These data suggest that the balance of IL-6 and IFN-α in the region of RNA virus infection may determine the number of peripheral Treg, which affects the effective immune responses against viruses. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/42641 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 瀬谷 司
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