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IL-6 and IFN-α from dsRNA-stimulated dendritic cells control expansion of regulatory T cells

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Title: IL-6 and IFN-α from dsRNA-stimulated dendritic cells control expansion of regulatory T cells
Authors: Kubota, Nobuhiko Browse this author
Ebihara, Takashi Browse this author
Matsumoto, Misako Browse this author
Gando, Satoshi Browse this author
Seya, Tsukasa Browse this author
Keywords: TICAM-1 (TRIF)
Dendritic cells
Regulatory T cells (Treg)
Issue Date: 15-Jan-2010
Publisher: Elsevier
Journal Title: Biochemical and Biophysical Research Communications
Volume: 391
Issue: 3
Start Page: 1421
End Page: 1426
Publisher DOI: 10.1016/j.bbrc.2009.12.081
PMID: 20026056
Abstract: Foxp3+CD4+ regulatory T cells (Treg) control not only autoinimunity but also the effective immune response against RNA virus infections, which produces virus-derived double-stranded RNA (dsRNA). To induce effective anti-viral immunity, it is a key issue to learn how Treg respond to dsRNA in vitro and in vivo. We here showed that synthetic dsRNA, polyI:C, caused peripheral expansion of functional Treg in a TICAM-1- and IL-6-dependent manner in vivo. PolyI:C did not expand Treg directly, but promoted the expansion of naturally occurring Treg indirectly through IL-6 produced from dendritic cells (DCs). In addition, the expansion of Treg by IL-6 was inhibited by IFN-α from polyI:C-stimulated DCs. These data suggest that the balance of IL-6 and IFN-α in the region of RNA virus infection may determine the number of peripheral Treg, which affects the effective immune responses against viruses.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 瀬谷 司

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