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Cellular expression of Bcl-2 and Bax in atrophic submandibular glands of rats

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タイトル: Cellular expression of Bcl-2 and Bax in atrophic submandibular glands of rats
その他のタイトル: Bcl-2 and Bax in salivary gland atrophy
著者: Takahashi, Shigeru 著作を一覧する
Yoshimura, Yoshitaka 著作を一覧する
Yamamoto, Tsuneyuki 著作を一覧する
Wakita, Minoru 著作を一覧する
キーワード: submandibular gland
duct-ligation
atrophy
apoptosis
Bcl-2
Bax
発行日: 2008年10月
出版者: Blackwell Publishing
誌名: International Journal of Experimental Pathology
巻: 89
号: 5
開始ページ: 303
終了ページ: 308
出版社 DOI: 10.1111/j.1365-2613.2008.00613.x
抄録: In submandibular gland atrophy, most acinar cells disappear by apoptosis, while many duct cells remain. The present study aimed to establish whether Bcl-2 and Bax, members of the Bcl-2 gene family, regulating the signaling pathway of apoptosis were involved in duct cell survival and acinar cell death in atrophic submandibular glands. The excretory duct of rat submandibular gland was doubly ligated with metal clips from 1 to 14 days to induce atrophy to the gland. The expressions of Bcl-2 and Bax in the atrophic submandibular gland were examined using immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). Immunohistochemically, Bcl-2 expression was identified in duct cells in the experimental glands at all time points. Some acinar cells showed Bax positivity 1 day after excretory duct ligation, and there were more Bax-positive acinar cells on days 3 and 5 when many apoptotic acinar cells were observed. RT-PCR analysis showed that the expression of mRNA for Bcl-2 became stronger as the glandular atrophy progressed and that Bax mRNA strongly expressed on days 1 and 3. These observations suggest that Bcl-2 inhibits duct cell apoptosis and Bax promotes apoptosis of acinar cells during atrophy of submandibular glands.
Rights: The definitive version is available at www.blackwell-synergy.com
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/42658
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 高橋 茂

 

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