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Cellular expression of Bcl-2 and Bax in atrophic submandibular glands of rats

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Title: Cellular expression of Bcl-2 and Bax in atrophic submandibular glands of rats
Other Titles: Bcl-2 and Bax in salivary gland atrophy
Authors: Takahashi, Shigeru Browse this author →KAKEN DB
Yoshimura, Yoshitaka Browse this author
Yamamoto, Tsuneyuki Browse this author
Wakita, Minoru Browse this author
Keywords: submandibular gland
Issue Date: Oct-2008
Publisher: Blackwell Publishing
Journal Title: International Journal of Experimental Pathology
Volume: 89
Issue: 5
Start Page: 303
End Page: 308
Publisher DOI: 10.1111/j.1365-2613.2008.00613.x
Abstract: In submandibular gland atrophy, most acinar cells disappear by apoptosis, while many duct cells remain. The present study aimed to establish whether Bcl-2 and Bax, members of the Bcl-2 gene family, regulating the signaling pathway of apoptosis were involved in duct cell survival and acinar cell death in atrophic submandibular glands. The excretory duct of rat submandibular gland was doubly ligated with metal clips from 1 to 14 days to induce atrophy to the gland. The expressions of Bcl-2 and Bax in the atrophic submandibular gland were examined using immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). Immunohistochemically, Bcl-2 expression was identified in duct cells in the experimental glands at all time points. Some acinar cells showed Bax positivity 1 day after excretory duct ligation, and there were more Bax-positive acinar cells on days 3 and 5 when many apoptotic acinar cells were observed. RT-PCR analysis showed that the expression of mRNA for Bcl-2 became stronger as the glandular atrophy progressed and that Bax mRNA strongly expressed on days 1 and 3. These observations suggest that Bcl-2 inhibits duct cell apoptosis and Bax promotes apoptosis of acinar cells during atrophy of submandibular glands.
Rights: The definitive version is available at
Type: article (author version)
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高橋 茂

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