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TRIM31 interacts with p52Shc and inhibits Src-induced anchorage-independent growth

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タイトル: TRIM31 interacts with p52Shc and inhibits Src-induced anchorage-independent growth
著者: Watanabe, Masashi 著作を一覧する
Tsukiyama, Tadasuke 著作を一覧する
Hatakeyama, Shigetsugu 著作を一覧する
キーワード: TRIM31
Gastrointestinal tract
TRIM family
発行日: 2009年10月16日
出版者: Elsevier
誌名: Biochemical and Biophysical Research Communications
巻: 388
号: 2
開始ページ: 422
終了ページ: 427
出版社 DOI: 10.1016/j.bbrc.2009.08.028
抄録: Tripartite motif-containing protein (TRIM) family proteins are involved in a broad range of biological processes and, consistently, their alterations result in diverse pathological conditions such as genetic diseases, viral infection and cancer development. In this study, we found that one of the TRIM family proteins, TRIM31, is highly expressed in the gastrointestinal tract and interacts with p52Shc, one of the signal transducers. We also found by a binding assay that almost the whole region other than the RING domain is required for the binding to p52Shc but found by pulse-chase analysis that overexpression of TRIM31 does not affect the stability of p52Shc. Moreover, we found that overexpression of TRIM31 suppresses anchorage-independent cell growth induced by the active form of c-Src. These results suggest that TRIM31 attenuates c-Src signaling via p52Shc under anchorage-independent growth conditions and is potentially associated with growth activity of cells in the gastrointestinal tract.
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 畠山 鎮次


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