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TRIM31 interacts with p52Shc and inhibits Src-induced anchorage-independent growth

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Title: TRIM31 interacts with p52Shc and inhibits Src-induced anchorage-independent growth
Authors: Watanabe, Masashi Browse this author
Tsukiyama, Tadasuke Browse this author
Hatakeyama, Shigetsugu Browse this author →KAKEN DB
Keywords: TRIM31
Ubiquitin
p52Shc
Gastrointestinal tract
TRIM family
Issue Date: 16-Oct-2009
Publisher: Elsevier
Journal Title: Biochemical and Biophysical Research Communications
Volume: 388
Issue: 2
Start Page: 422
End Page: 427
Publisher DOI: 10.1016/j.bbrc.2009.08.028
PMID: 19665990
Abstract: Tripartite motif-containing protein (TRIM) family proteins are involved in a broad range of biological processes and, consistently, their alterations result in diverse pathological conditions such as genetic diseases, viral infection and cancer development. In this study, we found that one of the TRIM family proteins, TRIM31, is highly expressed in the gastrointestinal tract and interacts with p52Shc, one of the signal transducers. We also found by a binding assay that almost the whole region other than the RING domain is required for the binding to p52Shc but found by pulse-chase analysis that overexpression of TRIM31 does not affect the stability of p52Shc. Moreover, we found that overexpression of TRIM31 suppresses anchorage-independent cell growth induced by the active form of c-Src. These results suggest that TRIM31 attenuates c-Src signaling via p52Shc under anchorage-independent growth conditions and is potentially associated with growth activity of cells in the gastrointestinal tract.
Type: article (author version)
URI: http://hdl.handle.net/2115/42700
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 畠山 鎮次

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