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Volume 57, Number 4 >

Genetic analysis of modifiers for the hooded phenotype in the rat

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Title: Genetic analysis of modifiers for the hooded phenotype in the rat
Authors: Torigoe, Daisuke Browse this author
Asano, Atsushi Browse this author
Yamauchi, Hideto Browse this author
Dang, Ruiha Browse this author
Sasaki, Nobuya Browse this author
Agui, Takashi Browse this author
Keywords: epistatic interaction
QTL analysis
rat coat color
Issue Date: Feb-2010
Publisher: Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 57
Issue: 4
Start Page: 175
End Page: 184
Abstract: The hooded phenotype is one of the coat color phenotype seen peculiarly in the rat. The hooded locus showing autosomal recessive inheritance is mapped to chromosome (Chr) 14 and that the hooded phenotype receives modification by hooded-modifier gene showing the linkage to the hooded locus. However, a gene responsible for either the hooded or hooded-modifier gene is not yet identified. To clarify genetic control of hooded phenotype, we carried out genetic linkage studies using BN and LEA rats. For determination of phenotypic variation, we measured ratio of pigmented coat area in parental and their F1 and F2 rats. We, then, conducted a genome-wide scan on 152 F2 rats for linkage with ratio of pigmented coat area for the dorsal, ventral, and total regions. A major quantitative trait locus (QTL), D14Got40, showing highly significant linkage contributing 70-90% of the variance for hooded phenotype was detected on Chr 14, which may be correspondent to the hooded locus. In addition, another QTL, D17Rat2, showing highly significant linkage was also detected on Chr 17 in dorsal region phenotype as well as a QTL showing suggestive linkage on Chr15 in ventral region phenotype. We, further, investigated a genome-wide scan for epistatic interactions and detected significant interactions between D14Got40 and D20Mit1, and between D14Got40 and D17Rat2 in the dorsal region phenotype. These results suggest that a major QTL in Chr 14, which is possibly correspondent to the hooded locus, mainly regulates the hooded phenotype with some modifier loci, two of which show epistatic interactions with the hooded locus.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 57, Number 4

Submitter: 獣医学部図書室

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