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Volume 57, Number 4 >

Evaluation of a new enzyme-linked immunosorbent assay to detect keratan sulfate in equine serum

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Title: Evaluation of a new enzyme-linked immunosorbent assay to detect keratan sulfate in equine serum
Authors: Lettry, Vivien Browse this author
Kawasaki, Hirofumi Browse this author
Sugaya, Kiyofumi Browse this author
Hosoya, Kenji Browse this author
Takagi, Satoshi Browse this author →KAKEN DB
Okumura, Masahiro Browse this author
Keywords: cartilage
keratan sulfate
Issue Date: Feb-2010
Publisher: Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 57
Issue: 4
Start Page: 207
End Page: 212
Abstract: This study aimed to evaluate a system that identifies cartilage turn over and/or degradation through measurement of a new keratan sulfate (KS) epitope concentration in equine sera. Blood samples were collected from 30 horses, 1 (n = 15) and 2 year-olds (n = 15). Serum samples were analyzed for an epitope of keratan sulfate by 1/20/5D4 (KS5D4) and new epitopes of keratan sulfate using high sensitive keratan sulfate (HSKS), measured by two respective enzyme-linked immunosorbant assays (ELISAs). There was no correlation in serum concentration of KS evaluated using 5D4 and HSKS. Age had no significant effect on concentrations of KS measured with KS5D4 while 1 year-old horses showed significantly higher amounts than 2 year-olds with HSKS. Results suggest that HSKS could detect early signs of cartilage metabolic changes.
Description: Note
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 57, Number 4

Submitter: 獣医学部図書室

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