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Butyrate-Induced Growth Inhibition and Differentiation in Caco-2 Cells with Hybrid Liposomes

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Title: Butyrate-Induced Growth Inhibition and Differentiation in Caco-2 Cells with Hybrid Liposomes
Authors: Hossain, Zakir Browse this author
Kurihara, Hideyuki Browse this author →KAKEN DB
Hosokawa, Masashi Browse this author →KAKEN DB
Takahashi, Koretaro Browse this author →KAKEN DB
Keywords: hybrid liposome
growth inhibition
Caco-2 cells
Issue Date: 2005
Publisher: Japan oil chemists' society
Journal Title: Journal of Oleo Science
Volume: 54
Issue: 5
Start Page: 281
End Page: 288
Abstract: Hybrid liposomes were prepared by mixing glycerophospholipids with glyceroglycolipids. The effects of hybrid liposomes on Caco-2 cells were investigated. Growth inhibition of cells was determined with sodium 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium dye reduction assay. Alkaline phosphatase activity was measured for assessing the cell differentiation induced by sodium butyrate (NaBT). Growth of Caco-2 cells was inhibited at 48 h after addition of all four types hybrid liposomes (PC/DGDG, PC/SQDG, PS/DGDG and PS/SQDG) while at 72 h growth inhibition was significant for all treatments except the hybrid liposome of phosphatidylcholine and digalactosyldiacylglycerol under concentrations of 50 μM glycerophospholipids with 50 μM glyceroglycolipids. Alkaline phosphatase activity of Caco-2 cells increased significantly when cells were treated in combination of hybrid liposomes and NaBT at 72 h, indicating that hybrid liposomes enhanced cell differentiation induced with NaBT.
Type: article
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高橋 是太郎

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