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Therapy of myeloma in vivo using marine phospholipid in combination with Agaricus blazei Muril as an immune respond activator

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Title: Therapy of myeloma in vivo using marine phospholipid in combination with Agaricus blazei Muril as an immune respond activator
Authors: Murakawa, Kentaro Browse this author
Fukunaga, Kenji Browse this author
Tanouchi, Masatoshi Browse this author
Hosokawa, Masashi Browse this author →KAKEN DB
Hossain, Zakir Browse this author
Takahashi, Koretaro Browse this author →KAKEN DB
Keywords: Agaricus blazei
marine phospholipid
myeloma
Issue Date: 2007
Publisher: Japan oil chemists' society
Journal Title: Journal of Oleo Science
Volume: 56
Issue: 4
Start Page: 179
End Page: 188
Abstract: Mushroom (Agaricus blazei Murill) extract has been reported to possess antitumor effects through immune activation. Here, we investigated the beneficial effects of combining A. blazei extract with marine phospholipids in comparison to A. blazei extract alone on myeloma sp2 tumor suppression when orally administrated. The experimental groups designed for sp2 tumor bearing BALB/c nu/nu mice were drinks of: (1)control; (2)1.0 mg/mL squid phospholipid liposome alone; (3)0.5 mg/mL A. blazei Murill water extract alone; (4)1.0 mg/mL squid phospholipid liposome with 0.5 mg/mL A. blazei Murill water extract in the form of those simple mixture; and (5)1.0 mg/mL squid phospholipid liposome with 0.5 mg/mL A. blazei Murill water extract partially encapsulated. Orally administrated volumes amounted to approximately 5 mL per day per mouse for all groups. A. blazei Murill water extract alone and squid phospholipid alone served groups show moderate tumor suppression with total administrations of approximately 105 mg/mouse for squid phospholipid through out the experimental term. When both A. blazei Murill water extract and squid phospholipid were administrated simultaneously in a simple mixture form, promotional effect on cancer tumor suppression was observed. And when A. blazei Murill water extract was partially encapsulated in the squid phospholipid liposomes with total administrations being 105 mg/mouse for squid phospholipid, effect on cancer tumor suppression was more pronounced. Though there was no statistically significant difference in tumor sizes between the simple mixture form administrated group i.e. group (4) and the partially encapsulated form administrated group i.e. group (5), the tumor vanished mouse was seen in the partially encapsulated form administrated group. Thus it was concluded that combinational administration of the A. blazei Murill water extract and the marine phospholipid may be useful in myeloma sp2 therapy.
Type: article
URI: http://hdl.handle.net/2115/42752
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高橋 是太郎

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