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Aberrant expression of HOX genes in human invasive breast carcinoma

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Title: Aberrant expression of HOX genes in human invasive breast carcinoma
Authors: Makiyama, Kokonoe Browse this author
Hamada, Jun-Ichi Browse this author
Takada, Minoru Browse this author
Murakawa, Katsuhiko Browse this author
Takahashi, Yoko Browse this author
Tada, Mitsuhiro Browse this author
Tamoto, Eiji Browse this author
Shindo, Gaku Browse this author
Matsunaga, Akihiro Browse this author
Teramoto, Ken-Ichi Browse this author
Komuro, Kazuteru Browse this author
Kondo, Satoshi Browse this author →KAKEN DB
Katoh, Hiroyuki Browse this author
Koike, Takao Browse this author
Moriuchi, Tetsuya Browse this author
Issue Date: Apr-2005
Publisher: Spandidos Publications
Journal Title: Oncology Reports
Volume: 13
Issue: 4
Start Page: 673
End Page: 679
PMID: 15756441
Abstract: HOX genes are known not only as master genes that control the morphogenesis, but also as regulator genes that maintain tissue or organ specificity in the adult body. We hypothesized that dysregulated expression of HOX genes was associated with tumor development and malignant progression such as invasion and metastasis. In this study, we analyzed the expression patterns of 39 HOX genes in human invasive ductal breast cancer tissues and normal tissues by the real-time RT-PCR method. We found 11 HOX genes (HOXA1, A2, A3, A5, A9, C11, D3, D4, D8, D9 and D10) expression levels of which were significantly different between cancerous and normal tissues. All 10 genes except HOXC11 were expressed at lower levels in cancerous tissues than normal tissues. Comparing expression levels of each HOX gene among the different types of cancer tissues, the expression level of HOXB7 was lower in lymph node metastasis-positive cancer tissues than negative cancer tissues; those of HOXD12 and D13 were higher in progesterone receptor-positive cancer tissues than negative cancer tissues; and the expression level of HOXC5 was lower in cancerous tissues with mutated-type p53 than in normal and cancerous tissues with wild-type p53. These results suggest that the aberrant expression of HOX genes is related to the development of breast cancer and malignant behavior of cancer cells.
Type: article
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 浜田 淳一

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