HIV-1 Vpr: A Novel Role in Regulating RNA Splicing


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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/42849

Title:	HIV-1 Vpr: A Novel Role in Regulating RNA Splicing
Authors:	Zhang, Xianfeng Browse this author →KAKEN DB
Authors:	Aida, Yoko Browse this author
Keywords:	HIV-1 Vpr
	splicing inhibition
	cellular pre-mRNA
	HIV-1 genome
	spliceosome
Issue Date:	Mar-2009
Publisher:	Bentham Science Publishers
Journal Title:	Current HIV Research
Volume:	7
Issue:	2
Start Page:	163
End Page:	168
PMID:	19275585
Abstract:	Pre-mRNA splicing is a critical step in gene expression for metazoans. Several viral proteins regulate the splicing of pre-mRNAs through complex interactions between the virus and the host cell RNA splicing machinery. Here, we focus on a novel function of HIV-1 Vpr, that selectively inhibit cellular and viral pre-mRNA splicing, via interactions with components of functional spliceosomal complexes. This review discusses our current knowledge of how RNA splicing regulation is accomplished by Vpr-host factors interactions.
Relation:	http://www.bentham.org/chivr/index.htm
Type:	article (author version)
URI:	http://hdl.handle.net/2115/42849
Appears in Collections:	遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 張険峰

OAI-PMH ( junii2 , jpcoar_1.0 )

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