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HIV-1 Vpr: A Novel Role in Regulating RNA Splicing

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Title: HIV-1 Vpr: A Novel Role in Regulating RNA Splicing
Authors: Zhang, Xianfeng Browse this author →KAKEN DB
Aida, Yoko Browse this author
Keywords: HIV-1 Vpr
splicing inhibition
cellular pre-mRNA
HIV-1 genome
Issue Date: Mar-2009
Publisher: Bentham Science Publishers
Journal Title: Current HIV Research
Volume: 7
Issue: 2
Start Page: 163
End Page: 168
PMID: 19275585
Abstract: Pre-mRNA splicing is a critical step in gene expression for metazoans. Several viral proteins regulate the splicing of pre-mRNAs through complex interactions between the virus and the host cell RNA splicing machinery. Here, we focus on a novel function of HIV-1 Vpr, that selectively inhibit cellular and viral pre-mRNA splicing, via interactions with components of functional spliceosomal complexes. This review discusses our current knowledge of how RNA splicing regulation is accomplished by Vpr-host factors interactions.
Type: article (author version)
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 張 険峰

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