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MEG time-frequency analyses for pre- and post-surgical evaluation of patients with epileptic rhythmic fast activity

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Title: MEG time-frequency analyses for pre- and post-surgical evaluation of patients with epileptic rhythmic fast activity
Authors: Sueda, Keitaro Browse this author
Takeuchi, Fumiya Browse this author
Shiraishi, Hideaki Browse this author
Nakane, Shingo Browse this author
Asahina, Naoko Browse this author
Kohsaka, Shinobu Browse this author
Nakama, Hideyuki Browse this author
Otsuki, Taisuke Browse this author
Sawamura, Yutaka Browse this author
Saitoh, Shinji Browse this author
Keywords: Magnetoencephalography
Fast activity
Fourier transform
Time-frequency analysis
Symptomatic localization-related epilepsy
Surgical evaluation
Issue Date: Feb-2010
Publisher: Elsevier B.V.
Journal Title: Epilepsy Research
Volume: 88
Issue: 2-3
Start Page: 100
End Page: 107
Publisher DOI: 10.1016/j.eplepsyres.2009.10.002
PMID: 19896803
Abstract: Purpose: To evaluate the effectiveness of surgery for epilepsy, we analyzed rhythmic fast activity by magnetoencephalography (MEG) before and after surgery using time-frequency analysis. To assess reliability, the results obtained by pre-surgical MEG and intraoperative electrocorticography were compared. Methods: Four children with symptomatic localization-related epilepsy caused by circumscribed cortical lesion were examined in the present study using 204 channel helmet-shaped MEG with a sampling rate of 600 Hz. One patient had dysembryoplastic neuroepithelial tumor (DNT) and three patients had focal cortical dysplasia (FCD). Aberrant areas were superimposed, to reconstruct 3-D MRI images, and illustrated as moving images. Results: In three patients, short-time Fourier transform (STFT) analyses of MEG showed rhythmic activities just above the lesion with FCD and in the vicinity of DNT. In one patient with FCD in the medial temporal lobe, rhythmic activity appeared in the ipsilateral frontal lobe and temporal lateral aspect. These findings correlate well with the results obtained by intraoperative electrocorticography. After the surgery, three patients were relieved of their seizures, and the area of rhythmic MEG activity disappeared or become smaller. One patient had residual rhythmic MEG activity, and she suffered from seizure relapse. Conclusion: Time-frequency analyses using STFT successfully depicted MEG rhythmic fast activity, and would provide valuable information for pre- and post-surgical evaluations to define surgical strategies for patients with epilepsy.
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 齋藤 伸治

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