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Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes

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Title: Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes
Authors: Araki, Atsuko Browse this author →KAKEN DB
Kawai, Toshio Browse this author
Eitaki, Yoko Browse this author
Kanazawa, Ayako Browse this author →KAKEN DB
Morimoto, Kanehisa Browse this author →KAKEN DB
Nakayama, Kunio Browse this author →KAKEN DB
Shibata, Eiji Browse this author →KAKEN DB
Tanaka, Masatoshi Browse this author
Takigawa, Tomoko Browse this author →KAKEN DB
Yoshimura, Takesumi Browse this author →KAKEN DB
Chikara, Hisao Browse this author
Saijo, Yasuaki Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Microbial volatile organic compounds (MVOC)
Home environment
Sick building syndrome
Mucous membrane
Issue Date: 15-Apr-2010
Publisher: Elsevier B.V.
Journal Title: Science of The Total Environment
Volume: 408
Issue: 10
Start Page: 2208
End Page: 2215
Publisher DOI: 10.1016/j.scitotenv.2010.02.012
PMID: 20188399
Abstract: Micro-organisms are known to produce a range of volatile organic compounds, so-called microbial VOC (MVOC). Chamber studies where humans were exposed to MVOC addressed the acute effects of objective and/or subjective signs of mucosal irritation. However, the effect of MVOC on inhabitants due to household exposure is still unclear. The purpose of this epidemiological study was to measure indoor MVOC levels in single family homes and to evaluate the relationship between exposure to them and sick building syndrome (SBS). All inhabitants of the dwellings were given a self-administered questionnaire with standardized questions to assess their symptoms. Air samples were collected and the concentrations of eight selected compounds in indoor air were analyzed by gas chromatography/mass spectrometry - selective ion monitoring mode (GC/MS-SIM). The most frequently detected MVOC was 1-pentanol at a detection rate of 78.6% and geometric mean of 0.60 μg/m3. Among 620 participants, 120 (19.4%) reported one or more mucous symptoms; irritation of the eyes, nose, airway, or coughing every week (weekly symptoms), and 30 (4.8%) reported that the symptoms were home-related (home-related symptoms). Weekly symptoms were not associated with any of MVOC. whereas significant associations between home-related mucous symptoms and 1-octen-3-ol (per log10-unit: odds ratio (OR) 5.6, 95% confidence interval (CI): 2.1 to 14.8) and 2-pentanol (per log10-unit: OR 2.3, 95% CI: 1.0 to 4.9) were obtained after adjustment for gender, age, and smoking. Associations between home-related symptoms and 1-octen-3-ol remained after mutual adjustment. However, concentrations of the selected compounds in indoors were lower than the estimated safety level in animal studies. Thus, the statistically significant association between 1-octen-3-ol may be due to a direct effect of the compounds or the associations may be being associated with other offending compounds. Additional studies are needed to evaluate these possibilities.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 荒木 敦子

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