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Involvement of the Central Thalamus in the Control of Smooth Pursuit Eye Movements

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Title: Involvement of the Central Thalamus in the Control of Smooth Pursuit Eye Movements
Authors: Tanaka, Masaki Browse this author →KAKEN DB
Keywords: eye movement
smooth pursuit
central thalamus
single unit
Issue Date: 22-Jun-2005
Publisher: Society for Neuroscience
Journal Title: Journal of Neuroscience
Volume: 25
Issue: 25
Start Page: 5866
End Page: 5876
Publisher DOI: 10.1523/JNEUROSCI.0676-05.2005
PMID: 15976075
Abstract: During maintenance of smooth pursuit eye movements, the brain must keep track of pursuit velocity to reconstruct target velocity from motion of retinal images. Although a recent study showed that corollary discharge signals through the thalamus to the cortex are used for internal monitoring of saccades, it remains unknown whether signals in the thalamus also contribute to monitoring and on-line regulation of smooth pursuit. The present study sought possible roles of the thalamocortical pathways in pursuit by recording activities of single thalamic neurons and by analyzing the effects of local inactivation. Data showed that many neurons in the ventrolateral thalamus exhibited directional modulation during pursuit. Most neurons discharged before or during initiation of pursuit, and the firing rate was proportional to the speed of target motion in a preferred direction.Whenthe tracking target was extinguished briefly during maintenance of pursuit, these neurons continued firing, indicating that they carried extra-retinal, eye movement signals. The majority of neurons showed no change in activity around the time of small catch-up saccades during pursuit but responded transiently to large (16°) memory-guided saccades in the preferred pursuit direction. Local inactivation of the recording sites did not alter pursuit latency but reduced eye velocity modestly during initiation and maintenance of ipsiversive pursuit. The results suggest that the central thalamus lies within pathways that regulate and monitor smooth pursuit eye movements.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 田中 真樹

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