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The Administration of Ciprofloxacin During Continuous Renal Replacement Therapy : Pilot Study

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Title: The Administration of Ciprofloxacin During Continuous Renal Replacement Therapy : Pilot Study
Authors: Hayakawa, Mineji Browse this author →KAKEN DB
Fujita, Itaru Browse this author
Iseki, Ken Browse this author
Gando, Satoshi Browse this author
Issue Date: May-2009
Publisher: Lippincott Williams & Wilkins
Journal Title: ASAIO Journal
Volume: 55
Issue: 3
Start Page: 243
End Page: 245
Publisher DOI: 10.1097/MAT.0b013e31819962b5
PMID: 19318919
Abstract: Continuous renal replacement therapy (CRRT) is a common technique in critically ill patients. However, there is no uniformity in the pharmacokinetics of ciprofloxacin (CPFX) used during CRRT. The aims of the present study were to estimate the pharmacokinetics of CPFX and to determine the appropriate administration of CPFX for critically ill patients undergoing CRRT. CPFX total clearance (CLtot) was calculated based on the creatinine clearance (CLcre), dialysate flow (QD) and ultrafiltrate flow (QF) as follow: CL_[tot (l/h)] = (4.83 CL_[cre (l/h)] + 6.41) + 0.92 (QD+Q_[F (l/h)]) base on in vitro study using CRRT circuit model. We administered CPFX to critically ill patients based on the CLtot, which was 50 x CL_[tot (l/h)] (mg/day). We confirmed that the CPFX concentrations reached higher than optimal concentrations and the infections were all successfully controlled in these patients.
Rights: This is a non-final version of an article published in final form in ASAIO Journal. 55(3):243-245, May/June 2009
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 早川 峰司

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