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The Administration of Ciprofloxacin During Continuous Renal Replacement Therapy : Pilot Study
| Title: | The Administration of Ciprofloxacin During Continuous Renal Replacement Therapy : Pilot Study |
| Authors: | Hayakawa, Mineji Browse this author →KAKEN DB | | Fujita, Itaru Browse this author | | Iseki, Ken Browse this author | | Gando, Satoshi Browse this author |
| Issue Date: | May-2009 |
| Publisher: | Lippincott Williams & Wilkins |
| Journal Title: | ASAIO Journal |
| Volume: | 55 |
| Issue: | 3 |
| Start Page: | 243 |
| End Page: | 245 |
| Publisher DOI: | 10.1097/MAT.0b013e31819962b5 |
| PMID: | 19318919 |
| Abstract: | Continuous renal replacement therapy (CRRT) is a common technique in critically ill patients. However, there is no uniformity in the pharmacokinetics of ciprofloxacin (CPFX) used during CRRT. The aims of the present study were to estimate the pharmacokinetics of CPFX and to determine the appropriate administration of CPFX for critically ill patients undergoing CRRT. CPFX total clearance (CLtot) was calculated based on the creatinine clearance (CLcre), dialysate flow (QD) and ultrafiltrate flow (QF) as follow: CL_[tot (l/h)] = (4.83 CL_[cre (l/h)] + 6.41) + 0.92 (QD+Q_[F (l/h)]) base on in vitro study using CRRT circuit model. We administered CPFX to critically ill patients based on the CLtot, which was 50 x CL_[tot (l/h)] (mg/day). We confirmed that the CPFX concentrations reached higher than optimal concentrations and the infections were all successfully controlled in these patients. |
| Rights: | This is a non-final version of an article published in final form in ASAIO Journal. 55(3):243-245, May/June 2009 |
| Relation: | http://www.asaiojournal.com/pt/re/asaio/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/43035 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 早川 峰司
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