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The Administration of Ciprofloxacin During Continuous Renal Replacement Therapy : Pilot Study

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タイトル: The Administration of Ciprofloxacin During Continuous Renal Replacement Therapy : Pilot Study
著者: Hayakawa, Mineji 著作を一覧する
Fujita, Itaru 著作を一覧する
Iseki, Ken 著作を一覧する
Gando, Satoshi 著作を一覧する
発行日: 2009年 5月
出版者: Lippincott Williams & Wilkins
誌名: ASAIO Journal
巻: 55
号: 3
開始ページ: 243
終了ページ: 245
出版社 DOI: 10.1097/MAT.0b013e31819962b5
抄録: Continuous renal replacement therapy (CRRT) is a common technique in critically ill patients. However, there is no uniformity in the pharmacokinetics of ciprofloxacin (CPFX) used during CRRT. The aims of the present study were to estimate the pharmacokinetics of CPFX and to determine the appropriate administration of CPFX for critically ill patients undergoing CRRT. CPFX total clearance (CLtot) was calculated based on the creatinine clearance (CLcre), dialysate flow (QD) and ultrafiltrate flow (QF) as follow: CL_[tot (l/h)] = (4.83 CL_[cre (l/h)] + 6.41) + 0.92 (QD+Q_[F (l/h)]) base on in vitro study using CRRT circuit model. We administered CPFX to critically ill patients based on the CLtot, which was 50 x CL_[tot (l/h)] (mg/day). We confirmed that the CPFX concentrations reached higher than optimal concentrations and the infections were all successfully controlled in these patients.
Rights: This is a non-final version of an article published in final form in ASAIO Journal. 55(3):243-245, May/June 2009
関連URI: http://www.asaiojournal.com/pt/re/asaio/
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/43035
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 早川 峰司

 

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