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Clinical characteristics of pleomorphic carcinoma of the lung
| Title: | Clinical characteristics of pleomorphic carcinoma of the lung |
| Authors: | Ito, Kenichiro Browse this author | | Oizumi, Satoshi Browse this author →KAKEN DB | | Fukumoto, Shinichi Browse this author | | Harada, Masao Browse this author | | Ishida, Takashi Browse this author | | Fujita, Yuka Browse this author | | Harada, Toshiyuki Browse this author | | Kojima, Tetsuya Browse this author | | Yokouchi, Hiroshi Browse this author | | Nishimura, Masaharu Browse this author →KAKEN DB | | Hokkaido Lung Cancer Clinical Study Group Browse this author |
| Keywords: | Pleomorphic carcinoma | | FDG-PET | | Surgery | | Chemotherapy | | Gefitinib | | Prognosis |
| Issue Date: | May-2010 |
| Publisher: | Elsevier Ireland |
| Journal Title: | Lung Cancer |
| Volume: | 68 |
| Issue: | 2 |
| Start Page: | 204 |
| End Page: | 210 |
| Publisher DOI: | 10.1016/j.lungcan.2009.06.002 |
| PMID: | 19577320 |
| Abstract: | Background: Pleomorphic carcinoma of the lung is a malignant epithelial tumor that contains carcinomatous and sarcomatoid components. Due to its rarity, few studies have been reported, and its clinical and pathological characteristics remain unclear. Method: We retrospectively investigated 22 cases of pleomorphic carcinoma of the lung. Results: Fifteen cases were diagnosed by surgical resection, four by autopsy, and three by transbronchial biopsy. Nineteen patients were male and three were female, and their mean age at diagnosis was 68.3 years (± 10.1). Eighteen were current- or ex-smokers with substantial smoking histories (mean 46.4 pack-years). Sixteen patients had symptoms: hemoptysis and cough were commonly seen. Chest computed tomography (CT) findings revealed that the tumors were quite large (mean diameter 45.3 ± 21.9 mm; range 14-110 mm), and 21 tumors were peripherally located. Positron emission tomography with 18-fluorodeoxy-glucose (FDG-PET) was performed in 12 patients, and the Standardized Uptake Value (SUV) tended to be high (9.44 ± 4.98). In the 15 patients who underwent surgical resection, recurrence was common; systemic metastases were also frequently found. Patients who had received surgical treatment with proper follow-up care survived longer than those who did not undergo surgery. Responses to chemotherapy were generally poor, although one patient exhibited partial response to gefitinib. Conclusions: Pulmonary pleomorphic carcinoma has strong malignant potential with frequent distant metastases, as has already been reported. However, this study demonstrated that surgical treatment and appropriate follow-up therapy might result in better prognoses. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/43068 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 大泉 聡史
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