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Generalized spike-wave discharges involve a default mode network in patients with juvenile absence epilepsy : A MEG study
| Title: | Generalized spike-wave discharges involve a default mode network in patients with juvenile absence epilepsy : A MEG study |
| Authors: | Sakurai, Kotaro Browse this author | | Takeda, Youji Browse this author | | Tanaka, Naoaki Browse this author | | Kurita, Tsugiko Browse this author | | Shiraishi, Hideaki Browse this author | | Takeuchi, Fumiya Browse this author | | Nakane, Shingo Browse this author | | Sueda, Keitaro Browse this author | | Koyama, Tsukasa Browse this author |
| Keywords: | Generalized spike-wave discharges | | Absence epilepsy | | Magnetoencephalography | | Default mode network | | Dynamic statistical parametric mapping |
| Issue Date: | May-2010 |
| Publisher: | Elsevier B.V. |
| Journal Title: | Epilepsy Research |
| Volume: | 89 |
| Issue: | 2-3 |
| Start Page: | 176 |
| End Page: | 184 |
| Publisher DOI: | 10.1016/j.eplepsyres.2009.12.004 |
| PMID: | 20061122 |
| Abstract: | This study uses magnetoencephalography (MEG) to examine whether cortical regions that constitute a default mode network are involved during generalized spike-wave discharges (GSWs) in patients with juvenile absence epilepsy (JAE). We studied five JAE patients for whom MEG was recorded using a 204-channel, whole-head gradiometer system. Dynamic statistical parametric mapping (dSPM) was done to estimate the cortical source distribution of GSW. The dSPM results showed strong medial prefrontal activation in all patients, with activation in the posterior cingulate and precuneus in three of five patients simultaneously or slightly after medial prefrontal activation. Furthermore, dSPM showed that the initial activation of a GSW appears in the focal cortical regions. Cortical regions that constitute a default mode network are strongly involved in the GSW process in some patients with JAE. Results also show that focal cortical activation appears at the onset of a GSW. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/43098 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 櫻井 高太郎
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