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Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction

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Title: Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction
Authors: Tosa, Noriko Browse this author →KAKEN DB
Iwai, Atsushi Browse this author
Tanaka, Taku Browse this author
Kumagai, Tomoka Browse this author
Nitta, Takeshi Browse this author
Chiba, Satoko Browse this author
Maeda, Masahiro Browse this author
Takahama, Yousuke Browse this author
Uede, Toshimitsu Browse this author
Miyazaki, Tadaaki Browse this author →KAKEN DB
Keywords: Apoptosis
Death-associated protein 3
Negative selection
T cell receptor
Issue Date: 7-May-2010
Publisher: Elsevier
Journal Title: Biochemical and Biophysical Research Communications
Volume: 395
Issue: 3
Start Page: 356
End Page: 360
Publisher DOI: 10.1016/j.bbrc.2010.04.018
PMID: 20381457
Abstract: Death associated protein 3 (DAP3) is crucial for promoting apoptosis induced by various stimulations. This report demonstrates that DAP3 is also important for T cell receptor (TCR)-mediated apoptosis induction in immature thymocytes. Enforced expression of DAP3 accelerated the negative selection in developing thymocytes, using the reaggregate thymus organ culture system. In addition, expression of DAP3 accelerated TCR-mediated apoptosis induction in DO11.10 cells. We also demonstrated that DAP3 translocates into the nucleus during TCR-mediated apoptosis in a Nur77 dependent manner. It is concluded that DAP3 is critical for TCR-mediated induction of apoptosis at the downstream of Nur77.
Type: article (author version)
Appears in Collections:人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮崎 忠昭

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