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Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction
| Title: | Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction |
| Authors: | Tosa, Noriko Browse this author →KAKEN DB | | Iwai, Atsushi Browse this author | | Tanaka, Taku Browse this author | | Kumagai, Tomoka Browse this author | | Nitta, Takeshi Browse this author | | Chiba, Satoko Browse this author | | Maeda, Masahiro Browse this author | | Takahama, Yousuke Browse this author | | Uede, Toshimitsu Browse this author | | Miyazaki, Tadaaki Browse this author →KAKEN DB |
| Keywords: | Apoptosis | | Death-associated protein 3 | | Negative selection | | Nur77 | | T cell receptor |
| Issue Date: | 7-May-2010 |
| Publisher: | Elsevier |
| Journal Title: | Biochemical and Biophysical Research Communications |
| Volume: | 395 |
| Issue: | 3 |
| Start Page: | 356 |
| End Page: | 360 |
| Publisher DOI: | 10.1016/j.bbrc.2010.04.018 |
| PMID: | 20381457 |
| Abstract: | Death associated protein 3 (DAP3) is crucial for promoting apoptosis induced by various stimulations. This report demonstrates that DAP3 is also important for T cell receptor (TCR)-mediated apoptosis induction in immature thymocytes. Enforced expression of DAP3 accelerated the negative selection in developing thymocytes, using the reaggregate thymus organ culture system. In addition, expression of DAP3 accelerated TCR-mediated apoptosis induction in DO11.10 cells. We also demonstrated that DAP3 translocates into the nucleus during TCR-mediated apoptosis in a Nur77 dependent manner. It is concluded that DAP3 is critical for TCR-mediated induction of apoptosis at the downstream of Nur77. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/43099 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮崎 忠昭
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