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Comparison of warfarin sensitivity between rat and bird species

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タイトル: Comparison of warfarin sensitivity between rat and bird species
著者: Watanabe, Kensuke P. 著作を一覧する
Saengtienchai, Aksorn 著作を一覧する
Tanaka, Kazuyuki D. 著作を一覧する
Ikenaka, Yoshinori 著作を一覧する
Ishizuka, Mayumi 著作を一覧する
キーワード: Avian
Cytochrome P450 (CYP)
Inhibitor constant (Ki)
Raptor
Vitamin K epoxide reductase (VKOR)
Vitamin K
Warfarin
発行日: 2010年 6月
出版者: Elsevier
誌名: Comparative Biochemistry and Physiology Part C : Toxicology & Pharmacology
巻: 152
号: 1
開始ページ: 114
終了ページ: 119
出版社 DOI: 10.1016/j.cbpc.2010.03.006
抄録: Scattering coumarin-derivative rodenticides in broad areas have caused primary- and secondary-poisoning incidents in non-target wild birds. In this study, we compared factors determining warfarin sensitivity between bird species and rats based on vitamin K 2,3-epoxide reductase (VKOR) kinetics, VKOR inhibition by warfarin and warfarin metabolism assays. In VKOR characterization, chickens and ostriches showed significantly lower enzymatic efficiencies than rats (one-sixth and one-third, respectively), suggesting bird species depend more on a non-VKOR vitamin K source. On the other hand, the inhibition constants (Ki) of VKOR for warfarin were significantly different between chickens and ostriches (113 ± 2.5 μM and 0.64 ± 0.39 μM, respectively). Interestingly, the ostrich Ki was similar to the values for rats (0.28 ± 0.09 μM). The Ki results reveal a surprising possibility that VKOR in some bird species are easily inhibited by warfarin. Warfarin metabolism assays also showed a large inter-species difference in bird species. Chickens and ostriches showed higher metabolic activity than that of rats, while mallards and owls showed only a slight ability to metabolize warfarin. In this study, we clarified the wide inter-species difference that exists among birds in xenobiotic metabolism and sensitivity to a rodenticide.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/43139
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 石塚 真由美

 

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