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Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis
| Title: | Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis |
| Authors: | Hirotani, Makoto Browse this author | | Niino, Masaaki Browse this author | | Fukazawa, Toshiyuki Browse this author | | Kikuchi, Seiji Browse this author | | Yabe, Ichiro Browse this author →KAKEN DB | | Hamada, Shinsuke Browse this author | | Tajima, Yasutaka Browse this author | | Sasaki, Hidenao Browse this author |
| Keywords: | MS | | TLR9 | | CpG DNA | | Immunoregulation |
| Issue Date: | 15-Apr-2010 |
| Publisher: | Elsevier B.V. |
| Journal Title: | Journal of Neuroimmunology |
| Volume: | 221 |
| Issue: | 1-2 |
| Start Page: | 95 |
| End Page: | 100 |
| Publisher DOI: | 10.1016/j.jneuroim.2010.02.012 |
| PMID: | 20227772 |
| Abstract: | The complexity of the roles of Toll-like receptors (TLRs) is attributable to their ability to promote or suppress autoimmune diseases. Recent studies have demonstrated that B cells regulate autoimmune diseases, including multiple sclerosis (MS), by producing interleukin (IL)-10. By using CpG DNA as a TLR9 agonist, we investigated the immunoregulatory functions of B cell via TLR9 in MS. Our results indicate that TLR9-mediated IL-10 production by B cells was significantly decreased in MS, and this decrease is likely due to decreased TLR9 expression in memory B cells, suggesting a role of TLR9 in immunoregulation in MS. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/43147 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 新野 正明
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