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Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis

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Title: Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis
Authors: Hirotani, Makoto Browse this author
Niino, Masaaki Browse this author
Fukazawa, Toshiyuki Browse this author
Kikuchi, Seiji Browse this author
Yabe, Ichiro Browse this author →KAKEN DB
Hamada, Shinsuke Browse this author
Tajima, Yasutaka Browse this author
Sasaki, Hidenao Browse this author
Keywords: MS
TLR9
CpG DNA
Immunoregulation
Issue Date: 15-Apr-2010
Publisher: Elsevier B.V.
Journal Title: Journal of Neuroimmunology
Volume: 221
Issue: 1-2
Start Page: 95
End Page: 100
Publisher DOI: 10.1016/j.jneuroim.2010.02.012
PMID: 20227772
Abstract: The complexity of the roles of Toll-like receptors (TLRs) is attributable to their ability to promote or suppress autoimmune diseases. Recent studies have demonstrated that B cells regulate autoimmune diseases, including multiple sclerosis (MS), by producing interleukin (IL)-10. By using CpG DNA as a TLR9 agonist, we investigated the immunoregulatory functions of B cell via TLR9 in MS. Our results indicate that TLR9-mediated IL-10 production by B cells was significantly decreased in MS, and this decrease is likely due to decreased TLR9 expression in memory B cells, suggesting a role of TLR9 in immunoregulation in MS.
Type: article (author version)
URI: http://hdl.handle.net/2115/43147
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 新野 正明

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