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Integrin β1-dependent invasive migration of irradiation-tolerant human lung adenocarcinoma cells in 3D collagen matrix

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タイトル: Integrin β1-dependent invasive migration of irradiation-tolerant human lung adenocarcinoma cells in 3D collagen matrix
著者: Ishihara, Seiichiro 著作を一覧する
Haga, Hisashi 著作を一覧する
Yasuda, Motoaki 著作を一覧する
Mizutani, Takeomi 著作を一覧する
Kawabata, Kazushige 著作を一覧する
Shirato, Hiroki 著作を一覧する
Nishioka, Takeshi 著作を一覧する
キーワード: Lung adenocarcinoma
Irradiation
3D culture
Collagen gel
Invasion
Integrin β1
発行日: 2010年 6月 4日
出版者: Elsevier
誌名: Biochemical and Biophysical Research Communications
巻: 396
号: 3
開始ページ: 651
終了ページ: 655
出版社 DOI: 10.1016/j.bbrc.2010.04.150
抄録: Radiotherapy is one of the effective therapies used for treating various malignant tumors. However, the emergence of tolerant cells after irradiation remains problematic due to their high metastatic ability, sometimes indicative of poor prognosis. In this study, we showed that subcloned human lung adenocarcinoma cells (A549P-3) that are irradiation-tolerant indicate high invasive activity in vitro, and exhibit an integrin β1 activity-dependent migratory pattern. In collagen gel overlay assay, majority of the A549P-3 cells displayed round morphology and low migration activity, whereas a considerable number of A549P-3IR cells surviving irradiation displayed a spindle morphology and high migration rate. Blocking integrin β1 activity reduced the migration rate of A549P-3IR cells and altered the cell morphology allowing them to assume a round shape. These results suggest that the A549P-3 cells surviving irradiation acquire a highly invasive integrin β1-dependent phenotype, and integrin β1 might be a potentially effective therapeutic target in combination with radiotherapy.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/43148
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 芳賀 永

 

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