| Title: | Pathophysiological Classification of Functional Dyspepsia Using a Novel Drinking-Ultrasonography Test |
| Authors: | Kato, Mototsugu Browse this author |
| Nishida, Urara Browse this author |
| Nishida, Mutsumi Browse this author |
| Hata, Tamotsu Browse this author |
| Asaka, Rumiko Browse this author |
| Haneda, Masahira Browse this author |
| Yamamoto, Keiko Browse this author |
| Imai, Aki Browse this author |
| Yoshida, Takeshi Browse this author |
| Ono, Shouko Browse this author |
| Shimizu, Yuichi Browse this author |
| Asaka, Masahiro Browse this author |
| Keywords: | Functional gastroduodenal disorders |
| Drink test |
| Visceral hypersensitivity |
| Gastric emptying |
| Gastric relaxation |
| Issue Date: | Jun-2010 |
| Publisher: | Karger |
| Journal Title: | Digestion |
| Volume: | 82 |
| Issue: | 3 |
| Start Page: | 162 |
| End Page: | 166 |
| Publisher DOI: | 10.1159/000308363 |
| PMID: | 20588028 |
| Abstract: | Background: Functional dyspepsia (FD) is a heterogeneous disease characterized by various upper abdominal symptoms. The major mechanism of FD symptoms includes impaired fundic accommodation, delayed gastric emptying, and visceral hypersensitivity. We developed a novel drinking-ultrasonography to combine a drink test with ultrasonography to assess gastric motility and sensory function of FD patients. Method: Subjects were sixty successive FD patients according to the Rome III criteria. A drinking-ultrasonography test was performed after subjects had fasted. The subjects ingested 200 ml of water at two-minute intervals four times (total 800 ml) through a straw. The maximum cross-section of the proximal stomach was visualized before water intake, after each water intake, and 5 and 10 minutes after the completion of drinking using extracorporeal ultrasonography. Abdominal symptoms were evaluated using the visual analog scale (VAS) a total of 5 times. Normal range of cross-sectional area and VAS were set using average ±2 standard deviations of 33 healthy volunteers. Cases outside the normal range were diagnosed with a motor or sensory disorder. Results: The drinking-ultrasonography test classified FD patients into four groups without adverse effect or trouble. The distribution of each group was 27% in the normal group, 15% in the impaired relaxation group, 10% in the delayed emptying group, and 48% in the visceral hypersensitivity group. There was no significant correlation between the pathophysiological classification and subtypes of FD defined by the Rome III criteria. Conclusion: We developed a novel drinking-ultrasonography test that was effective in classifying FD patients according to pathophysiological features. |
| Rights: | Copyright © 2010 S. Karger AG, Basel |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/43267 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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