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Pathophysiological Classification of Functional Dyspepsia Using a Novel Drinking-Ultrasonography Test

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タイトル: Pathophysiological Classification of Functional Dyspepsia Using a Novel Drinking-Ultrasonography Test
著者: Kato, Mototsugu 著作を一覧する
Nishida, Urara 著作を一覧する
Nishida, Mutsumi 著作を一覧する
Hata, Tamotsu 著作を一覧する
Asaka, Rumiko 著作を一覧する
Haneda, Masahira 著作を一覧する
Yamamoto, Keiko 著作を一覧する
Imai, Aki 著作を一覧する
Yoshida, Takeshi 著作を一覧する
Ono, Shouko 著作を一覧する
Shimizu, Yuichi 著作を一覧する
Asaka, Masahiro 著作を一覧する
キーワード: Functional gastroduodenal disorders
Drink test
Visceral hypersensitivity
Gastric emptying
Gastric relaxation
発行日: 2010年 6月
出版者: Karger
誌名: Digestion
巻: 82
号: 3
開始ページ: 162
終了ページ: 166
出版社 DOI: 10.1159/000308363
抄録: Background: Functional dyspepsia (FD) is a heterogeneous disease characterized by various upper abdominal symptoms. The major mechanism of FD symptoms includes impaired fundic accommodation, delayed gastric emptying, and visceral hypersensitivity. We developed a novel drinking-ultrasonography to combine a drink test with ultrasonography to assess gastric motility and sensory function of FD patients. Method: Subjects were sixty successive FD patients according to the Rome III criteria. A drinking-ultrasonography test was performed after subjects had fasted. The subjects ingested 200 ml of water at two-minute intervals four times (total 800 ml) through a straw. The maximum cross-section of the proximal stomach was visualized before water intake, after each water intake, and 5 and 10 minutes after the completion of drinking using extracorporeal ultrasonography. Abdominal symptoms were evaluated using the visual analog scale (VAS) a total of 5 times. Normal range of cross-sectional area and VAS were set using average ±2 standard deviations of 33 healthy volunteers. Cases outside the normal range were diagnosed with a motor or sensory disorder. Results: The drinking-ultrasonography test classified FD patients into four groups without adverse effect or trouble. The distribution of each group was 27% in the normal group, 15% in the impaired relaxation group, 10% in the delayed emptying group, and 48% in the visceral hypersensitivity group. There was no significant correlation between the pathophysiological classification and subtypes of FD defined by the Rome III criteria. Conclusion: We developed a novel drinking-ultrasonography test that was effective in classifying FD patients according to pathophysiological features.
Rights: Copyright © 2010 S. Karger AG, Basel
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 加藤 元嗣


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