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Pathophysiological Classification of Functional Dyspepsia Using a Novel Drinking-Ultrasonography Test

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Title: Pathophysiological Classification of Functional Dyspepsia Using a Novel Drinking-Ultrasonography Test
Authors: Kato, Mototsugu Browse this author
Nishida, Urara Browse this author
Nishida, Mutsumi Browse this author
Hata, Tamotsu Browse this author
Asaka, Rumiko Browse this author
Haneda, Masahira Browse this author
Yamamoto, Keiko Browse this author
Imai, Aki Browse this author
Yoshida, Takeshi Browse this author
Ono, Shouko Browse this author
Shimizu, Yuichi Browse this author
Asaka, Masahiro Browse this author
Keywords: Functional gastroduodenal disorders
Drink test
Visceral hypersensitivity
Gastric emptying
Gastric relaxation
Issue Date: Jun-2010
Publisher: Karger
Journal Title: Digestion
Volume: 82
Issue: 3
Start Page: 162
End Page: 166
Publisher DOI: 10.1159/000308363
PMID: 20588028
Abstract: Background: Functional dyspepsia (FD) is a heterogeneous disease characterized by various upper abdominal symptoms. The major mechanism of FD symptoms includes impaired fundic accommodation, delayed gastric emptying, and visceral hypersensitivity. We developed a novel drinking-ultrasonography to combine a drink test with ultrasonography to assess gastric motility and sensory function of FD patients. Method: Subjects were sixty successive FD patients according to the Rome III criteria. A drinking-ultrasonography test was performed after subjects had fasted. The subjects ingested 200 ml of water at two-minute intervals four times (total 800 ml) through a straw. The maximum cross-section of the proximal stomach was visualized before water intake, after each water intake, and 5 and 10 minutes after the completion of drinking using extracorporeal ultrasonography. Abdominal symptoms were evaluated using the visual analog scale (VAS) a total of 5 times. Normal range of cross-sectional area and VAS were set using average ±2 standard deviations of 33 healthy volunteers. Cases outside the normal range were diagnosed with a motor or sensory disorder. Results: The drinking-ultrasonography test classified FD patients into four groups without adverse effect or trouble. The distribution of each group was 27% in the normal group, 15% in the impaired relaxation group, 10% in the delayed emptying group, and 48% in the visceral hypersensitivity group. There was no significant correlation between the pathophysiological classification and subtypes of FD defined by the Rome III criteria. Conclusion: We developed a novel drinking-ultrasonography test that was effective in classifying FD patients according to pathophysiological features.
Rights: Copyright © 2010 S. Karger AG, Basel
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 元嗣

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