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Natural Killer T Cells Are Involved in Adipose Tissues Inflammation and Glucose Intolerance in Diet-Induced Obese Mice

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Title: Natural Killer T Cells Are Involved in Adipose Tissues Inflammation and Glucose Intolerance in Diet-Induced Obese Mice
Authors: Ohmura, Kazue Browse this author
Ishimori, Naoki Browse this author →KAKEN DB
Ohmura, Yoshinori Browse this author
Tokuhara, Satoshi Browse this author
Nozawa, Atsushi Browse this author
Horii, Shunpei Browse this author
Andoh, Yasuhiro Browse this author
Fujii, Satoshi Browse this author
Iwabuchi, Kazuya Browse this author
Onoé, Kazunori Browse this author
Tsutsui, Hiroyuki Browse this author →KAKEN DB
Keywords: obesity
natural killer T cells
macrophages
visceral adipose tissues
glucose intolerance
Issue Date: 1-Feb-2010
Publisher: American Heart Association
Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology
Volume: 30
Issue: 2
Start Page: 193
End Page: 199
Publisher DOI: 10.1161/ATVBAHA.109.198614
PMID: 19910631
Abstract: Objective: Macrophage as well as lymphocyte infiltration in adipose tissue may contribute to the pathogenesis of obesity-mediated metabolic disorders. Natural killer T (NKT) cells, which integrate proinflammatory cytokines, have been demonstrated in the atherosclerotic lesions and also in visceral adipose tissue. We thus determined whether NKT cells are involved in glucose intolerance and adipose tissue inflammation in diet-induced obese mice. Methods and Results: To determine whether NKT cells are involved in the development of glucose intolerance, male β2 microglobulin knockout mice lacking NKT cells (KO) and C57BL/6J (WT) mice were fed with a high fat diet (HFD) for 13 weeks. Body weight and visceral obesity were comparable between WT and KO mice. However, macrophage infiltration was reduced in adipose tissue and glucose intolerance was significantly ameliorated in KO mice. To further confirm that NKT cells are involved in these abnormalities, α-galactosylceramide (αGC, 0.1μg/g body weight), which specifically activates NKT cells, were administered after 13 weeks of HFD feeding. αGC significantly exacerbated glucose intolerance and also macrophage infiltration as well as cytokine gene expression in adipose tissue. Conclusions: NKT cells play a crucial role in the development of adipose tissue inflammation and glucose intolerance in diet-induced obesity.
Type: article (author version)
URI: http://hdl.handle.net/2115/43323
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石森 直樹

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