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Phylogenetic and expression analysis of lamprey toll-like receptors

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Title: Phylogenetic and expression analysis of lamprey toll-like receptors
Authors: Kasamatsu, Jun Browse this author
Oshiumi, Hiroyuki Browse this author →KAKEN DB
Matsumoto, Misako Browse this author →KAKEN DB
Kasahara, Masanori Browse this author
Seya, Tsukasa Browse this author
Keywords: Toll-like receptor
Innate immunity
Issue Date: Aug-2010
Publisher: Elsevier
Journal Title: Developmental & Comparative Immunology
Volume: 34
Issue: 8
Start Page: 855
End Page: 865
Publisher DOI: 10.1016/j.dci.2010.03.004
PMID: 20363250
Abstract: Toll-like receptors (TLRs) have been identified as pivotal sensors recognizing microbial pattern molecules in vertebrates. Whole genome analysis of the teleost Takifugu rubripes supports the existence of a fundamental family of TLR genes in fish. However, the role of the innate immune system in the context of raising acquired immunity in jawless fish remains unclear. In this study, we annotated 16 lamprey TLR genes predicted from the latest genome assembly of lamprey on the basis of homology, and identified their cDNAs from Japanese lamprey, Lethenteron japonicum. Phylogenetic analyses indicated that the repertoire of lamprey TLRs consisted of both fish (F)- and mammalian (M)-type TLRs, and it was also demonstrated that lamprey TLRs are constitutively expressed in various organs. Our results suggest that lampreys protect against microorganisms using the innate system consisting of a similar set of M- and F-type TLRs, despite possessing a unique acquired immune system. In addition, type I interferon (IFN), interferon regulatory factor (IRF)-3, and IRF7 were not identified in the lamprey genome although TLR adaptor and signal transduction genes were highly conserved upstream of (IRF)-3/7 and type I IFN in most vertebrates. This is the first report to describe the TLR repertoire and IFN system in one of the most primitive vertebrates, the lamprey.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 瀬谷 司

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