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Endogenous acetylcholine modulates impulsive action via α4β2 nicotinic acetylcholine receptors in rats
| Title: | Endogenous acetylcholine modulates impulsive action via α4β2 nicotinic acetylcholine receptors in rats |
| Authors: | Tsutsui-Kimura, Iku Browse this author | | Ohmura, Yu Browse this author | | Izumi, Takeshi Browse this author | | Yamaguchi, Taku Browse this author | | Yoshida, Takayuki Browse this author | | Yoshioka, Mitsuhiro Browse this author |
| Keywords: | Impulsivity | | Impulsive behavior | | Response inhibition | | Premature responding | | Attention-deficit/hyperactivity disorder | | 5-choice serial reaction time task |
| Issue Date: | 1-Sep-2010 |
| Publisher: | Elsevier B.V. |
| Journal Title: | European Journal of Pharmacology |
| Volume: | 641 |
| Issue: | 2-3 |
| Start Page: | 148 |
| End Page: | 153 |
| Publisher DOI: | 10.1016/j.ejphar.2010.05.028 |
| PMID: | 20639140 |
| Abstract: | Nicotine has been well established as an impulsive action-inducing agent, but it remains unknown whether endogenous acetylcholine affects impulsive action via nicotinic acetylcholine receptors. In the present study, the 3-choice serial reaction time task (3-CSRTT), a simple and valid assessment of impulsive action, was employed. Male Wistar/ST rats were trained to detect and respond to 1-s flashes of light presented in one of three holes until stable performance was achieved. Following training on the 3-CSRTT, rats received intracerebroventricular injections of the preferential α4β2 nicotinic acetylcholine receptor antagonist dihydro-β-erythroidine (DHβE; 0, 3, 10, and 30μg) or the selective α7 nicotinic acetylcholine receptor antagonist methyllycaconitine (MLA: 0, 3, 10, and 30 μg) 5 min before test sessions. Injection of 10 μg of DHβE significantly suppressed premature responses, an index of impulsive-like action, without changing other behavioral parameters. On the other hand, MLA infusions failed to affect impulsive-like action at any dose. These results suggest that the central α4β2 nicotinic acetylcholine receptors that enable a provoking effect of endogenous acetylcholine play a critical role in impulsive action. Substances that modulate nicotinic acetylcholine receptors, especially the α4β2 subtype, may be beneficial for the treatment of psychiatric disorders characterized by lack of inhibitory control. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/43803 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 木村 生
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