Title: | Clinical Value and Limitations of [11C]-Methionine PET for Detection and Localization of Suspected Parathyroid Adenomas |
Authors: | Herrmann, Ken Browse this author |
Takei, Toshiki Browse this author |
Kanegae, Kakuko Browse this author →KAKEN DB |
Shiga, Tohru Browse this author →KAKEN DB |
Buck, Andreas K. Browse this author |
Altomonte, Jennifer Browse this author |
Schwaiger, Markus Browse this author |
Schuster, Tibor Browse this author |
Nishijima, Kenichi Browse this author |
Kuge, Yuji Browse this author →KAKEN DB |
Tamaki, Nagara Browse this author →KAKEN DB |
Keywords: | MET-PET |
MIBI scintigraphy |
Ultrasound |
Hyperparathyroidism |
Diagnosis |
Issue Date: | Sep-2009 |
Publisher: | Springer New York |
Journal Title: | Molecular Imaging and Biology |
Volume: | 11 |
Issue: | 5 |
Start Page: | 356 |
End Page: | 363 |
Publisher DOI: | 10.1007/s11307-009-0205-4 |
PMID: | 19340488 |
Abstract: | Purpose: The aim of this study was to assess the clinical value of [11C]methionine-PET (MET-PET) for detection and localization of parathyroid adenomas in patients without prior thyroidectomy. Methods: A retrospective analysis of patients with suspected hyperparathyroidism undergoing imaging with MET-PET was performed. Prior thyroidectomy was an exclusion criterion. 41 patients with a total of 49 MET-PET scans were included. MET-PET consisted of whole-body images obtained 15 - 20 min after injection of 430 ± 81 MBq of MET using a dedicated PET scanner. Imaging findings were validated by histology or other imaging studies and clinical follow-up on a lesion, side and location basis. Comparison of PET results to other imaging modalities including ultrasound, MIBI scintigraphy and morphological imaging (CT and/or MRI) and subgroup analysis of primary vs. secondary hyperparathyroidism was performed. Results: 23/49 PET scans revealed pathologic findings, whereas 26/49 scans were negative. Validation of PET findings for detection and localization of hyperthyroidism resulted in an overall sensitivity of MET-PET of 54%, 49% and 35% on a lesion, side and location basis, respectively. Sensitivity of MET-PET was inferior compared to ultrasonography (50% vs. 93%), MIBI scintigraphy (53% vs. 74%) and morphological imaging (52% vs. 74%). Subgroup analysis revealed higher sensitivity for MET-PET in sHPT than pHPT (62% vs. 43%; side basis). Conclusions: In patients with initial diagnosis of hyperparathyroidism and no prior thyroidectomy, the sensitivity of MET-PET for detection and localization of hyperparathyroidism is markedly lower compared to previous reports. While performance was better in sHPT, MET-PET can not be recommended for pHPT localization in this clinically relevant subcollective. |
Rights: | The original publication is available at www.springerlink.com |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/43808 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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