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Hokkaido University Collection of Scholarly and Academic Papers >
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The effects of serotionin and/or noradrenaline reuptake inhibitors on impulsive-like action assessed by the three-choice serial reaction time task : a simple and valid model of impulsive action using rats
| Title: | The effects of serotionin and/or noradrenaline reuptake inhibitors on impulsive-like action assessed by the three-choice serial reaction time task : a simple and valid model of impulsive action using rats |
| Authors: | Tsutsui-Kimura, Iku Browse this author | | Ohmura, Yu Browse this author | | Izumi, Takeshi Browse this author →KAKEN DB | | Yamaguchi, Taku Browse this author | | Yoshida, Takayuki Browse this author | | Yoshioka, Mitsuhiro Browse this author →KAKEN DB |
| Keywords: | atomoxetine | | fluvoxamine | | impulsive action | | impulsivity | | milnacipran | | nicotine | | three-choice serial reaction time task |
| Issue Date: | Sep-2009 |
| Publisher: | Lippincott Williams & Wilkins |
| Journal Title: | Behavioural Pharmacology |
| Volume: | 20 |
| Issue: | 5-6 |
| Start Page: | 474 |
| End Page: | 483 |
| Publisher DOI: | 10.1097/FBP.0b013e3283305e65 |
| PMID: | 19730368 |
| Abstract: | Impulsivity is a pathological symptom in several psychiatric disorders, underscoring the need for animal models of impulsive action to develop a brief screening method for novel therapeutic agents of impulsive action. Our goals were (1) to evaluate whether the 3-choice serial reaction time task (3-CSRTT), a simple version of the 5-choice serial reaction time task (5-CSRTT), is appropriate for brief assessment of impulsive-like action and (2) to examine effects of fluvoxamine, a selective serotonin reuptake inhibitor, and milnacipran, a serotonin/noradrenaline reuptake inhibitor, on impulsive-like action using the 3-CSRTT. Following training in the 3-CSRTT, rats were administered nicotine (0, 0.1, 0.2, and 0.4 mg/kg, salt, s.c.), atomoxetine (0, 0.01, 0.1, and, 1.0 mg/kg, i.p.), fluvoxamine (0, 2, 4, and 8 mg/kg, i.p.), or milnacipran (0, 3, and 10 mg/kg, i.p.). The training time for the 3-CSRTT was significantly shorter than that for the 5-CSRTT. Nicotine increased, while atomoxetine decreased the number of premature responses, an index of impulsive-like action, which is consistent with previous studies. Moreover, we found that milnacipran, but not fluvoxamine, dose-dependently decreased premature responses. These results indicate that the 3-CSRTT could provide an appropriate and simpler rodent model of impulsive-like action and that milnacipran could have some beneficial effects on impulsivity-related disorders. |
| Rights: | This is a non-final version of an article published in final form in Behavioural Pharmacology, September 2009, 20(5-6), 474-483. |
| Relation: | http://journals.lww.com/behaviouralpharm/pages/default.aspx |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/43814 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 泉 剛
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