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Duration and Booster Effect of Phylactic Response against White Spot Syndrome Virus Infection in Kuruma Shrimp Orally Administrated with Recombinant Viral Proteins, rVP26 and rVP28

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Title: Duration and Booster Effect of Phylactic Response against White Spot Syndrome Virus Infection in Kuruma Shrimp Orally Administrated with Recombinant Viral Proteins, rVP26 and rVP28
Authors: Satoh, Jun Browse this author →KAKEN DB
Nishizawa, Toyohiko Browse this author →KAKEN DB
Yoshimizu, Mamoru Browse this author →KAKEN DB
Keywords: white spot syndrome virus
WSSV
quasi-immune response
kuruma shrimp
oral vaccination
phylaxis
booster effect
PRDV
Issue Date: Sep-2009
Publisher: Japanese Society of Fish Pathology
Journal Title: Fish Pathology
Journal Title(alt): 魚病研究
Volume: 44
Issue: 3
Start Page: 120
End Page: 127
Publisher DOI: 10.3147/jsfp.44.120
Abstract: White spot syndrome virus (WSSV: a synonym of penaeid rod-shaped DNA virus, PRDV) is the causative agent of white spot disease (WSD: penaeid acute viremia, PAV), one of the most serious diseases affecting decapod crustaceans around the world. Recently, "quasi-immune response" was found in kuruma shrimp Penaeus japonicus, wherein individuals that naturally survived from WSD showed protection against a rechallenge with WSSV. The phylaxis against WSSV was also inducible by oral vaccination with recombinant WSSV proteins, rVP26 and rVP28. In the present study, kuruma shrimp orally vaccinated with rVPs were sequentially challenged with WSSV to evaluate onset and duration of phylactic response and booster effect. The phylactic response of shrimp against WSSV-challenge peaked at day 45 after the vaccination with rVP26 (RPS: 100%) and at day 55 with rVP28 (RPS: 93%), and decreased within 10-20 days. The phylaxis against WSSV-challenge was boosted by the secondary vaccination with homologous rVPs, but not by those with heterologous rVPs. The peaks of phylactic responses appeared at day 22 after the secondary vaccination more rapidly than those after the primary vaccination. These results demonstrated that the duration of phylaxis induced by oral vaccination with rVPs was relatively short, but could be extended by booster vaccination with homologous rVPs.
Type: article
URI: http://hdl.handle.net/2115/43818
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 西澤 豊彦

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