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Duration and Booster Effect of Phylactic Response against White Spot Syndrome Virus Infection in Kuruma Shrimp Orally Administrated with Recombinant Viral Proteins, rVP26 and rVP28

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この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/43818

タイトル: Duration and Booster Effect of Phylactic Response against White Spot Syndrome Virus Infection in Kuruma Shrimp Orally Administrated with Recombinant Viral Proteins, rVP26 and rVP28
著者: Satoh, Jun 著作を一覧する
Nishizawa, Toyohiko 著作を一覧する
Yoshimizu, Mamoru 著作を一覧する
キーワード: white spot syndrome virus
WSSV
quasi-immune response
kuruma shrimp
oral vaccination
phylaxis
booster effect
PRDV
発行日: 2009年 9月
出版者: Japanese Society of Fish Pathology
誌名: Fish Pathology = 魚病研究
巻: 44
号: 3
開始ページ: 120
終了ページ: 127
出版社 DOI: 10.3147/jsfp.44.120
抄録: White spot syndrome virus (WSSV: a synonym of penaeid rod-shaped DNA virus, PRDV) is the causative agent of white spot disease (WSD: penaeid acute viremia, PAV), one of the most serious diseases affecting decapod crustaceans around the world. Recently, "quasi-immune response" was found in kuruma shrimp Penaeus japonicus, wherein individuals that naturally survived from WSD showed protection against a rechallenge with WSSV. The phylaxis against WSSV was also inducible by oral vaccination with recombinant WSSV proteins, rVP26 and rVP28. In the present study, kuruma shrimp orally vaccinated with rVPs were sequentially challenged with WSSV to evaluate onset and duration of phylactic response and booster effect. The phylactic response of shrimp against WSSV-challenge peaked at day 45 after the vaccination with rVP26 (RPS: 100%) and at day 55 with rVP28 (RPS: 93%), and decreased within 10-20 days. The phylaxis against WSSV-challenge was boosted by the secondary vaccination with homologous rVPs, but not by those with heterologous rVPs. The peaks of phylactic responses appeared at day 22 after the secondary vaccination more rapidly than those after the primary vaccination. These results demonstrated that the duration of phylaxis induced by oral vaccination with rVPs was relatively short, but could be extended by booster vaccination with homologous rVPs.
資料タイプ: article
URI: http://hdl.handle.net/2115/43818
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 西澤 豊彦

 

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