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The applications of time-frequency analyses to ictal magnetoencephalography in neocortical epilepsy

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Title: The applications of time-frequency analyses to ictal magnetoencephalography in neocortical epilepsy
Authors: Yagyu, Kazuyori Browse this author
Takeuchi, Fumiya Browse this author
Shiraishi, Hideaki Browse this author
Nakane, Shingo Browse this author
Sueda, Keitaro Browse this author
Asahina, Naoko Browse this author
Kohsaka, Shinobu Browse this author
Umeoka, Shuichi Browse this author
Usui, Naotaka Browse this author
Baba, Koichi Browse this author
Saitoh, Shinji Browse this author
Keywords: Ictal onset
Propagation
Polyspike
Short-time Fourier transform
Ictal discharge
Rhythmic activities
Issue Date: Aug-2010
Publisher: Elsevier B.V.
Journal Title: Epilepsy Research
Volume: 90
Issue: 3
Start Page: 199
End Page: 206
Publisher DOI: 10.1016/j.eplepsyres.2010.05.001
PMID: 20605700
Abstract: Purpose: Ictal magenetoencephalographic (MEG) discharges convey significant information about ictal onset and propagation, but there is no established method for analyzing ictal MEG. This study sought to clarify the usefulness of time-frequency analyses using short-time Fourier transform (STFT) for ictal onset and propagation of ictal MEG activity in patients with neocortical epilepsy. Methods: Four ictal MEG discharges in two patients with perirolandic epilepsy and one with frontal lobe epilepsy (FLE) were evaluated by time-frequency analyses using STFT. Prominent oscillation bands were collected manually and the magnitudes of those specific bands were superimposed on individual 3D-magnetic resonance images. Results: STFT showed specific rhythmic activities from alpha to beta bands at the magnetological onset in all four ictal MEG records. Those activities were located at the vicinity of interictal spike sources, as estimated by the single dipole method (SDM), and two of the four ictal rhythmic activities promptly propagated to ipsilateral or bilateral cerebral cortices. The patients with FLE and perirolandic epilepsy underwent frontal lobectomy and resection of primary motor area, respectively including the origin of high-magnitude areas of a specific band indicated by STFT, and have been seizure free after the surgery. Conclusions: STFT for ictal MEG discharges readily demonstrated the ictal onset and propagation. These data were important for decisions on surgical procedure and extent of resection. Ictal MEG analyses using STFT could provide a powerful tool for noninvasive evaluation of ictal onset zone.
Type: article (author version)
URI: http://hdl.handle.net/2115/43835
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 柳生 一自

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