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Outcome of surgical treatment of hilar cholangiocarcinoma : a special reference to postoperative morbidity and mortality

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Title: Outcome of surgical treatment of hilar cholangiocarcinoma : a special reference to postoperative morbidity and mortality
Authors: Hirano, Satoshi Browse this author
Kondo, Satoshi Browse this author
Tanaka, Eiichi Browse this author →KAKEN DB
Shichinohe, Toshiaki Browse this author
Tsuchikawa, Takahiro Browse this author
Kato, Kentaro Browse this author
Matsumoto, Joe Browse this author
Kawasaki, Ryosuke Browse this author
Keywords: Hilar cholangiocarcinoma
Hilar bile duct resection
Issue Date: Jul-2010
Publisher: Springer Japan
Journal Title: Journal of Hepato-Biliary-Pancreatic Sciences
Volume: 17
Issue: 4
Start Page: 455
End Page: 462
Publisher DOI: 10.1007/s00534-009-0208-1
PMID: 19820891
Abstract: Background/Purpose: Radical resection for hilar cholangiocarcinoma is still associated with significant morbidity and mortality. The aim of this study was to analyze short-term surgical outcomes and to validate our strategies, including preoperative management and selection of operative procedure. Methods: We surgically treated 146 consecutive patients with hilar cholangiocarcinoma with a management strategy consisting of preoperative biliary drainage, portal vein embolization, and selection of operative procedure based on tumor extension and hepatic reserve. Major hepatectomy was conducted in 126 patients, and caudate lobectomy or hilar bile duct resection in 20 patients. Results: The overall 5-year survival rate was 35.5%, with overall in-hospital mortality and morbidity rates of 3.4% and 44%, respectively. Hyperbilirubinemia (total bilirubin > 5 mg/dL, persisted for > 7 postoperative days) and liver abscess were the most frequent complications. Five among 9 patients with liver failure (total bilirubin > 10 mg/dL) encountered in-hospital mortality. Four out of 5 mortality patients had suffered circulatory impairment of the remnant liver due to other complications. Multivariate analysis revealed that operative time is a single independent significant predictive factor (odds ratio, 1.005; 95% confidence interval, 1.000-1.010, P = 0.04) for postoperative complications. Conclusions: Aggressive resection for hilar cholangiocarcinoma, performed in accordance with strict management strategy, achieved acceptable low mortality. Prolonged operative time was a risk for morbidity following hepatobiliary resection.
Rights: The original publication is available at
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 平野 聡

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