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Inhibitory effects of epigallocatechin-3 gallate, a polyphenol in green tea, on tumor-associated endothelial cells and endothelial progenitor cells

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Title: Inhibitory effects of epigallocatechin-3 gallate, a polyphenol in green tea, on tumor-associated endothelial cells and endothelial progenitor cells
Authors: Ohga, Noritaka Browse this author
Hida, Kyoko Browse this author →KAKEN DB
Hida, Yasuhiro Browse this author
Muraki, Chikara Browse this author
Tsuchiya, Kunihiko Browse this author
Matsuda, Kohei Browse this author
Ohiro, Yoichi Browse this author
Totsuka, Yasunori Browse this author
Shindoh, Masanobu Browse this author
Issue Date: Oct-2009
Publisher: Wiley-Blackwell
Journal Title: Cancer Science
Volume: 100
Issue: 10
Start Page: 1963
End Page: 1970
Publisher DOI: 10.1111/j.1349-7006.2009.01255.x
Abstract: The polyphenol epigallocatechin-3 gallate (EGCG) in green tea suppresses tumor growth by direct action on tumor cells and by inhibition of angiogenesis, but it is not known whether it specifically inhibits tumor angiogenesis. We examined the anti-angiogenic effect of EGCG on tumor-associated endothelial cells (TECs), endothelial progenitor cells (EPCs), and normal endothelial cells (NECs). EGCG suppressed the migration of TECs and EPCs but not NECs. EGCG also inhibited the phosphorylation of Akt in TECs but not in NECs. Furthermore, vascular endothelial growth factor-induced mobilization of EPCs into circulation was inhibited by EGCG. Matrix metalloproteinase-9 (MMP-9) in the bone marrow plasma plays key roles in EPC mobilization into circulation. We observed that expression of MMP-9 mRNA was downregulated by EGCG in mouse bone marrow stromal cells. In vivo model, EGCG suppressed growth of melanoma and reduced microvessel density. Our study showed that EGCG has selective anti-angiogenic effects on TECs and EPC. It is suggested that EGCG could be a promising angiogenesis inhibitor for cancer therapy.
Rights: The definitive version is available at www.blackwell-synergy.com
Type: article (author version)
URI: http://hdl.handle.net/2115/43937
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 樋田 京子

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