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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
Peer-reviewed Journal Articles, etc >
Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma
| Title: | Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma |
| Authors: | Sato, Jun Browse this author | | Goto, Jun Browse this author | | Murata, Tsubasa Browse this author | | Kitamori, Shogo Browse this author | | Yamazaki, Yutaka Browse this author | | Satoh, Akira Browse this author | | Kitagawa, Yoshimasa Browse this author |
| Keywords: | interleukin-6 | | saliva | | oral | | squamous cell carcinoma | | carcinogenesis |
| Issue Date: | Sep-2010 |
| Publisher: | Mosby |
| Journal Title: | Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology |
| Volume: | 110 |
| Issue: | 3 |
| Start Page: | 330 |
| End Page: | 336 |
| Publisher DOI: | 10.1016/j.tripleo.2010.03.040 |
| PMID: | 20598594 |
| Abstract: | Objective: To elucidate the changes in interleukin-6 (IL-6) levels in whole saliva during the treatment phase in patients with oral squamous cell carcinoma (OSCC). Study design: Twenty-nine consecutive inpatients with OSCC were enrolled in this study. Stimulated saliva was collected three times (just after hospitalization)[period 1], just before main treatment (surgery: 26/29 cases)[period 2] and at the time of discharge [period 3]. The mean intervals were 11±8 days between periods 1 and 2 and 30±18 days between periods 2 and 3. As controls, 19 age-matched healthy volunteers were also recruited. IL-6 concentrations were measured by a highly sensitive chemiluminescent enzyme immunoassay. Results: IL-6 was detected in 23/29 samples in the patient group in period 1. The concentration of IL-6 was significantly higher in the patient group (mean: 20.1±36.3 pg/mL) than in the controls (0.6±0.8 pg/mL)(P = 0.003). In the patient group, the mean concentration of IL-6 in period 2 was 43.6±95.6 pg/mL, significantly higher than in period 1 (P=0.002), and 17.1±27.6 pg/mL in period 3 (P=0.52: compared with period 2). Conclusions: IL-6 was up-regulated in saliva in the OSCC patients. IL-6 level tended to increase before treatment, and returned to baseline levels at discharge. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/43950 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 佐藤 淳
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