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Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma

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Title: Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma
Authors: Sato, Jun Browse this author
Goto, Jun Browse this author
Murata, Tsubasa Browse this author
Kitamori, Shogo Browse this author
Yamazaki, Yutaka Browse this author
Satoh, Akira Browse this author
Kitagawa, Yoshimasa Browse this author
Keywords: interleukin-6
saliva
oral
squamous cell carcinoma
carcinogenesis
Issue Date: Sep-2010
Publisher: Mosby
Journal Title: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Volume: 110
Issue: 3
Start Page: 330
End Page: 336
Publisher DOI: 10.1016/j.tripleo.2010.03.040
PMID: 20598594
Abstract: Objective: To elucidate the changes in interleukin-6 (IL-6) levels in whole saliva during the treatment phase in patients with oral squamous cell carcinoma (OSCC). Study design: Twenty-nine consecutive inpatients with OSCC were enrolled in this study. Stimulated saliva was collected three times (just after hospitalization)[period 1], just before main treatment (surgery: 26/29 cases)[period 2] and at the time of discharge [period 3]. The mean intervals were 11±8 days between periods 1 and 2 and 30±18 days between periods 2 and 3. As controls, 19 age-matched healthy volunteers were also recruited. IL-6 concentrations were measured by a highly sensitive chemiluminescent enzyme immunoassay. Results: IL-6 was detected in 23/29 samples in the patient group in period 1. The concentration of IL-6 was significantly higher in the patient group (mean: 20.1±36.3 pg/mL) than in the controls (0.6±0.8 pg/mL)(P = 0.003). In the patient group, the mean concentration of IL-6 in period 2 was 43.6±95.6 pg/mL, significantly higher than in period 1 (P=0.002), and 17.1±27.6 pg/mL in period 3 (P=0.52: compared with period 2). Conclusions: IL-6 was up-regulated in saliva in the OSCC patients. IL-6 level tended to increase before treatment, and returned to baseline levels at discharge.
Type: article (author version)
URI: http://hdl.handle.net/2115/43950
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐藤 淳

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