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A role of the Ca2+ binding site of DC-SIGN in the phagocytosis of E. coli

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タイトル: A role of the Ca2+ binding site of DC-SIGN in the phagocytosis of E. coli
著者: Iyori, Mitsuhiro 著作を一覧する
Ohtani, Makoto 著作を一覧する
Hasebe, Akira 著作を一覧する
Totsuka, Yasunori 著作を一覧する
Shibata, Ken-ichiro 著作を一覧する
発行日: 2008年10月10日
出版者: Academic Press
誌名: Biochemical and biophysical research communications
巻: 377(2)
開始ページ: 367
終了ページ: 372
抄録: HEK293 cells stably expressing DC-SIGN (293/DC-SIGN) were examined for phagocytosis of Escherichia coli. 293/DC-SIGN stable transfectants were able to mediate phagocytosis of E. coli. The phagocytosis was inhibited by EDTA or several inhibitors specific for Syk kinase, Raf kinase and the transcription factor NF-􀀁B.DC-SIGN consists of characteristic domains and motifs such as CRD, neck, incomplete ITAM, dileucine and tri-acidic cluster. HEK293 cells expressing mutants of DC-SIGN were also examined for the phagocytosis. It was found that Ca2+ binding sites in the CRD of DC-SIGN were involved in phagocytosis of bacteria as well as multimerization of DC-SIGN, and the neck region played a role in efficiency of binding to microbes as well as multimerization of the protein.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/43954
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 柴田 健一郎

 

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