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Resveratrol modulates phagocytosis of bacteria through an NF-κB-dependent gene program

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Title: Resveratrol modulates phagocytosis of bacteria through an NF-κB-dependent gene program
Authors: Iyori, Mitsuhiro Browse this author
Kataoka, Hideo Browse this author
Shamsul, Haque Browse this author
Kiura, Kazuto Browse this author
Yasuda, Motoaki Browse this author
Nakata, Takashi Browse this author
Hasebe, Akira Browse this author
Shibata, Ken-ichiro Browse this author →KAKEN DB
Issue Date: 22-Feb-2007
Publisher: American Society for Microbiology
Journal Title: American Society for Microbiology
Volume: 52(2)
Start Page: 121
End Page: 127
Publisher DOI: 10.1128/AAC.00210-07
PMID: 17938187
Abstract: Many studies have shown that the pharmacological effects of resveratrol, a phytoalexin polyphenolic compound, include protective effects against cancer and inflammation as well as enhancement of stress resistance. In this study, we examined whether resveratrol affected phagocytosis of bacteria by macrophages and activation of the transcription factor NF-κB after stimulation with or without the ligand FSL-1 for Toll-like receptor 2 (TLR2). Both phagocytosis of E. coli or S. aureus by THP-1 cells or RAW264.7 cells was inhibited by resveratrol in a dose-dependent manner regardless of stimulation with FSL-1. The NF-κB activity in HEK293 cells stably expressing TLR2 was also inhibited by resveratrol after stimulation with FSL-1. Resveratrol also inhibited both the translocation of p65 of NF-κB into nuclei in the transfectant and TNF-α production by THP-1 cells or RAW264.7 cells. It has recently been reported that TLR-mediated signaling pathways lead to upregulation of mRNAs of phagocytic receptors, including scavenger receptors and C-type lectin receptors.This study also demonstrated that FSL-1 induced upregulation of mRNAs of phagocytic receptors such as macrophage scavenger receptor-1, CD36, DC-SIGN and Dectin-1, and the FSL-1-induced upregulation of their mRNAs was inhibited by resveratrol. In addition, it was found that the expression of DC-SIGN in HEK293 cells stably expressing DC-SIGN was reduced by resveratrol and the phagocytic activity was significantly inhibited by resveratrol. Thus, this study suggested that resveratrol inhibited the bacterial phagocytosis by macrophages by downregulating the expression of phagocytic receptors and the NF-κB activity.
Type: article (author version)
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 柴田 健一郎

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