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The diacylated lipopeptide FSL-1 enhances phagocytosis of bacteria by macrophages through Toll-like receptor 2-mediated signaling pathway

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タイトル: The diacylated lipopeptide FSL-1 enhances phagocytosis of bacteria by macrophages through Toll-like receptor 2-mediated signaling pathway
著者: Mae, Masako 著作を一覧する
Iyori, Mitsuhiro 著作を一覧する
Yasuda, Motoaki 著作を一覧する
Shamsul, Haque 著作を一覧する
Kataoka, Hideo 著作を一覧する
Kiura, Kazuto 著作を一覧する
Hasebe, Akira 著作を一覧する
Totsuka, Yasunori 著作を一覧する
Shibata, Ken-ichiro 著作を一覧する
キーワード: Toll-like receptor 2
the lipopeptide FSL-1,
phagocytosis
macrophage
発行日: 2007年 2月22日
出版者: Blackwell
誌名: FEMS immunology and medical microbiology
巻: 49
開始ページ: 398
終了ページ: 409
出版社 DOI: 10.1111/j.1574-695X.2007.00218.x
抄録: Enormous lines of evidence have been accumulated that Toll-like receptors (TLRs) function as sensors for microbial invasion. However, less is known about how signaling triggered by TLRs leads to phagocytosis of pathogens. This study was designed to determine whether stimulation of TLR2 with mainly the lipopeptide FSL-1 plays a role in phagocytosis of pathogens by macrophages. FSL-1 markedly enhanced phagocytosis of E. coli more strongly than that of S. aureus, but did not enhance phagocytosis of latex beads. FSL-1 stimulation resulted in enhanced phagocytosis of bacteria by macrophages from TLR2+/+mice but not those from TLR2-/- mice. Chinese hamster ovary cells stably expressing TLR2 failed tophagocytose these bacteria, but the cells expressing CD14 did. FSL-1 induced upregulation of the expression of phagocytic receptors including MSR1, CD36, DC-SIGN and Dectin-1 in THP-1 cells.Human embryonic kidney 293 cells transfected with DC-SIGN and MSR1 phagocytosed these bacteria. These results suggest that the FSL-1-induced enhancement of phagocytosis of bacteria by acrophages may be explained partially by the upregulation of scavenger receptors and the C-type lectins through TLR2-mediated signaling pathways and that TLR2 by itself does not function as a phagocytic receptor.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/43975
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 柴田 健一郎

 

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