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The synthetic analogue of mycoplasmal lipoprotein FSL-1 induces dendritic cell maturation through

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Title: The synthetic analogue of mycoplasmal lipoprotein FSL-1 induces dendritic cell maturation through
Authors: Kiura, Kazuto Browse this author
Kataoka, Hideo Browse this author
Nakata, Takashi Browse this author
Into, Takeshi Browse this author
Yasuda, Motoaki Browse this author
Akira, Shizuo Browse this author
Inoue, Nobuo Browse this author
Shibata, Ken-ichiro Browse this author →KAKEN DB
Keywords: Dendritic cells
Toll-like receptor 2,
lipopeptide
ipopolysaccharide
Issue Date: Feb-2006
Publisher: Blackwell
Journal Title: FEMS immunology and medical microbiology
Volume: 46(1)
Start Page: 78
End Page: 84
Publisher DOI: 10.1111/j.1574-695X.2005.00002.x
PMID: 16420600
Abstract: GM-CSF-differentiated bone marrow-derived DCs (BMDCs) were stimulated with FSL-1 or E.coli LPS. FSL-1 induced the production of TNF-α and IL-12 by C57BL/6-derived BMDCs but not by BMDCs from Toll-like receptor 2-deficient (TLR2-/-) mice, whereas LPS induced the production of TNF-α and IL-12 by BMDCs derived from either type of mice. FSL-1 did not induce production of IL-10 by BMDCs from either type of mice, whereas LPS induced small amounts of IL-10 by BMDCs from both types of mice. FSL-1 upregulated the expression of CD80, CD86 and the MHC class II molecule IAb in both dose- and time-dependent manners on the surfaces of C57BL/6-derived BMDCs but not on the surface of TLR2-/--derived BMDCs, whereas LPS upregulated the expression of them on the surfaces of BMDCs from both types of mice. The expression of CD11c on the surfaces of C57BL/6-derived BMDCs was upregulated by stimulation with both FSL-1 and LPS up to 12 h and then the expression was downregulated.The results suggest that FSL-1 has activity to accelerate maturation of BMDCs and that the activity of FSL-1 is mediated by TLR2.
Type: article (author version)
URI: http://hdl.handle.net/2115/43979
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 柴田 健一郎

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