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The synthetic analogue of mycoplasmal lipoprotein FSL-1 induces dendritic cell maturation through
Title: | The synthetic analogue of mycoplasmal lipoprotein FSL-1 induces dendritic cell maturation through |
Authors: | Kiura, Kazuto Browse this author | Kataoka, Hideo Browse this author | Nakata, Takashi Browse this author | Into, Takeshi Browse this author | Yasuda, Motoaki Browse this author | Akira, Shizuo Browse this author | Inoue, Nobuo Browse this author | Shibata, Ken-ichiro Browse this author →KAKEN DB |
Keywords: | Dendritic cells | Toll-like receptor 2, | lipopeptide | ipopolysaccharide |
Issue Date: | Feb-2006 |
Publisher: | Blackwell |
Journal Title: | FEMS immunology and medical microbiology |
Volume: | 46 |
Issue: | 1 |
Start Page: | 78 |
End Page: | 84 |
Publisher DOI: | 10.1111/j.1574-695X.2005.00002.x |
PMID: | 16420600 |
Abstract: | GM-CSF-differentiated bone marrow-derived DCs (BMDCs) were stimulated with FSL-1 or E.coli LPS. FSL-1 induced the production of TNF-α and IL-12 by C57BL/6-derived BMDCs but not by BMDCs from Toll-like receptor 2-deficient (TLR2-/-) mice, whereas LPS induced the production of TNF-α and IL-12 by BMDCs derived from either type of mice. FSL-1 did not induce production of IL-10 by BMDCs from either type of mice, whereas LPS induced small amounts of IL-10 by BMDCs from both types of mice. FSL-1 upregulated the expression of CD80, CD86 and the MHC class II molecule IAb in both dose- and time-dependent manners on the surfaces of C57BL/6-derived BMDCs but not on the surface of TLR2-/--derived BMDCs, whereas LPS upregulated the expression of them on the surfaces of BMDCs from both types of mice. The expression of CD11c on the surfaces of C57BL/6-derived BMDCs was upregulated by stimulation with both FSL-1 and LPS up to 12 h and then the expression was downregulated.The results suggest that FSL-1 has activity to accelerate maturation of BMDCs and that the activity of FSL-1 is mediated by TLR2. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/43979 |
Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 柴田 健一郎
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