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The synthetic analogue of mycoplasmal lipoprotein FSL-1 induces dendritic cell maturation through

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タイトル: The synthetic analogue of mycoplasmal lipoprotein FSL-1 induces dendritic cell maturation through
著者: Kiura, Kazuto 著作を一覧する
Kataoka, Hideo 著作を一覧する
Nakata, Takashi 著作を一覧する
Into, Takeshi 著作を一覧する
Yasuda, Motoaki 著作を一覧する
Akira, Shizuo 著作を一覧する
Inoue, Nobuo 著作を一覧する
Shibata, Ken-ichiro 著作を一覧する
キーワード: Dendritic cells
Toll-like receptor 2,
lipopeptide
ipopolysaccharide
発行日: 2006年 2月
出版者: Blackwell
誌名: FEMS immunology and medical microbiology
巻: 46(1)
開始ページ: 78
終了ページ: 84
出版社 DOI: 10.1111/j.1574-695X.2005.00002.x
抄録: GM-CSF-differentiated bone marrow-derived DCs (BMDCs) were stimulated with FSL-1 or E.coli LPS. FSL-1 induced the production of TNF-α and IL-12 by C57BL/6-derived BMDCs but not by BMDCs from Toll-like receptor 2-deficient (TLR2-/-) mice, whereas LPS induced the production of TNF-α and IL-12 by BMDCs derived from either type of mice. FSL-1 did not induce production of IL-10 by BMDCs from either type of mice, whereas LPS induced small amounts of IL-10 by BMDCs from both types of mice. FSL-1 upregulated the expression of CD80, CD86 and the MHC class II molecule IAb in both dose- and time-dependent manners on the surfaces of C57BL/6-derived BMDCs but not on the surface of TLR2-/--derived BMDCs, whereas LPS upregulated the expression of them on the surfaces of BMDCs from both types of mice. The expression of CD11c on the surfaces of C57BL/6-derived BMDCs was upregulated by stimulation with both FSL-1 and LPS up to 12 h and then the expression was downregulated.The results suggest that FSL-1 has activity to accelerate maturation of BMDCs and that the activity of FSL-1 is mediated by TLR2.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/43979
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 柴田 健一郎

 

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