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Synergic effects of mycoplasmal lipopeptides and extracellular ATP on activation of macrophages

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タイトル: Synergic effects of mycoplasmal lipopeptides and extracellular ATP on activation of macrophages
著者: INTO, TAKESHI 著作を一覧する
FUJITA, MARI 著作を一覧する
OKUSAWA, TSUGUMI 著作を一覧する
HASEBE, AKIRA 著作を一覧する
MORITA, MANABU 著作を一覧する
SHIBATA, KEN-ICHIRO 著作を一覧する
発行日: 2002年 7月
出版者: American Society For Microbiology
誌名: Infection and immunity
巻: 70(7)
開始ページ: 3586
終了ページ: 3591
出版社 DOI: 10.1128/IAI.70.7.3586-3591.2002
抄録: Mycoplasmal lipopeptides, S-(2,3-bispalmitoyloxypropyl)-CGDPKHSPKSF and S-(2,3-bispalmitoyloxypropyl)-CGNNDESNISFKEK activated a monocytic cell line,THP-1 cells, to produce tumor necrosis factor-α. The activity of the lipopeptides was augmented by ATP added in a dose-dependent manner. In addition, the level of the expression of mRNAs of tumor necrosis factor-α, interleukin-1β, -6 and -8 was also up-regulated by the lipopeptides and/or extracellular ATP, but that of interleukin-10 was not. The P2X purinergic receptor antagonists pyridoxal phosphate 6-azophenyl 2’,4’-disulfonic acid and periodate oxidized ATP suppressed the activity of ATP to augment the activation of THP-1 cells by the lipopeptides, suggesting that P2X receptors play important roles in the activity of ATP. The nuclear factor-κB inhibitor dexamethasone also suppressed the activity,suggesting that the activity of ATP is dependent upon the nuclear factor-κB.Thus, these results suggest that the interaction of extracellular ATP with the P2X receptors is attributed to the activity of ATP to augment the activation of THP-1 cells by mycoplasmal lipopeptides.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/43983
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 柴田 健一郎

 

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