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Strong adhesion of Saos-2 cells to multi-walled carbon nanotubes

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Title: Strong adhesion of Saos-2 cells to multi-walled carbon nanotubes
Authors: Matsuoka, Makoto Browse this author
Akasaka, Tsukasa Browse this author
Totsuka, Yasunori Browse this author
Watari, Fumio Browse this author
Keywords: Carbon nanotubes
Osteoblast
Adhesion
Vinculin
Issue Date: 15-Oct-2010
Publisher: Elsevier B.V.
Journal Title: Materials Science and Engineering B
Volume: 173
Issue: 1-3
Start Page: 182
End Page: 186
Publisher DOI: 10.1016/j.mseb.2009.12.044
Abstract: In recent years, carbon nanotubes (CNTs) have been considered potential biomedical materials because of their unique character. The aim of this study was to investigate the response of a human osteoblast-like cell line - Saos-2 - on single-walled CNTs (SWCNTs) and multi-walled CNTs (MWCNTs). The surface of a culture dish was coated with CNTs, and Saos-2 cells were cultured for three days. Cell morphology, viability, alkaline phosphatase (ALP) activity, adhesion, and vinculin expression were evaluated. The result showed high cell viability and strong adhesion to MWCNTs. Saos-2 cultured on MWCNTs exhibited vinculin expression throughout the cell body. while the cells attached to SWCNTs and glass were mostly limited to their periphery. Our results suggest that CNT coatings promote cell activity and adhesiveness. These findings indicate that MWCNTs could be used as surface coating materials to promote cell adhesion.
Type: article (author version)
URI: http://hdl.handle.net/2115/44027
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松岡 真琴

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