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Carotenoids as regulators for inter-species difference in Cytochrome P450 1A expression and activity in ungulates and rats

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Title: Carotenoids as regulators for inter-species difference in Cytochrome P450 1A expression and activity in ungulates and rats
Authors: Darwish, Wageh S. Browse this author
Ikenaka, Yoshinori Browse this author →KAKEN DB
Ohno, Marumi Browse this author
Eldaly, Elsaid A. Browse this author
Ishizuka, Mayumi Browse this author →KAKEN DB
Keywords: Carotenoids
Correlation
Cytochrome P450 1A
Ungulates
Issue Date: Nov-2010
Publisher: Elsevier
Journal Title: Food and Chemical Toxicology
Volume: 48
Issue: 11
Start Page: 3201
End Page: 3208
Publisher DOI: 10.1016/j.fct.2010.08.022
PMID: 20797421
Abstract: Ungulates (deer, cattle and horses) are reported as animal species which show extreme-accelerated metabolism of CYP1A substrates, such as ethoxyresorufin compared to rats. This study was undertaken to investigate whether accumulation of carotenoids is a possible cause for inter-species difference in CYP1A-dependent activity in this group of animals. The relationship between inter-species differences in CYP1A-dependent activity and the accumulated carotenoids and retinoids as candidates of dietary CYP1A inducers in ungulate species was clarified. Interestingly, there were positive correlations between the accumulated carotenoids, such as β-carotene, with both EROD activity and CYP1A protein expression. These correlations were negative with the accumulated retinoids, such as retinol. The β-carotene was major component of carotenoids in ungulates, and known as an inducer of CYP1A. On the other hand, the retinol is reported as the inhibitor of CYP1A. Other factors which affect CYP1A1 expression, such as polycyclic aromatic hydrocarbons, were also analyzed. To cancel the effects of inter-species difference in CYP1A induction signal cascade among these animals, the rat cell line (H4-II-cells) was treated with the extracted carotenoids from the examined animals. In conclusion, carotenoids and retinoids may have direct effects on the inter-species differences in CYP1A-dependent activity and protein expression.
Relation: http://www.sciencedirect.com
Type: article (author version)
URI: http://hdl.handle.net/2115/44086
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石塚 真由美

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