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Long-term oral administration of cows' milk improves insulin sensitivity in rats fed a high-sucrose diet

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Title: Long-term oral administration of cows' milk improves insulin sensitivity in rats fed a high-sucrose diet
Authors: Matsumoto, Megumi Browse this author
Inoue, Ryo Browse this author
Tsuruta, Takeshi Browse this author
Hara, Hiroshi Browse this author
Yajima, Takaji Browse this author
Keywords: Cows' milk
Insulin sensitivity
Intestinal microbiota
Rats
Issue Date: Nov-2009
Publisher: Cambridge University Press
Journal Title: British Journal of Nutrition
Volume: 102
Issue: 9
Start Page: 1324
End Page: 1333
Publisher DOI: 10.1017/S0007114509990365
PMID: 19566967
Abstract: We evaluated the effects of long-term daily cows' milk (CM) administration on insulin resistance induced by a high-sucrose diet. F344 rats, aged 3 weeks, were divided into two groups according to diet (dextrin-fed v. sucrose-fed). These groups were further divided into two groups receiving either CM or artificial milk (AM; isoenergetic emulsion of egg white protein, maltose, lard and minerals). Rats were fed a sucrose- or dextrin-based diet for 7 weeks and orally administered CM or AM at 25 ml/kg following an 8 h fast on a daily basis. Insulin sensitivity was evaluated via postprandial changes in serum glucose and insulin, oral glucose tolerance tests, and fasting serum insulin and fructosamine concentrations. The sucrose-fed rats showed an overall decrease in insulin sensitivity, but postprandial insulin levels were lower in the CM-treated subgroup than in the AM-treated subgroup. Peak serum glucose and insulin concentrations were highest in the sucrose-fed rats, but CM administration reduced peak glucose and insulin values in comparison with AM administration. By area under the curve analysis, insulin levels after feeding and glucose loads were significantly lower in the CM-treated groups than in the AM-treated groups. The CM-treated groups also demonstrated lower fasting insulin and fructosamine levels than the AM-treated groups. Improved insulin sensitivity due to CM administration seemed to be associated with reduced duodenal GLUT2 mRNA levels and increased propionate production within the caecum.
Relation: http://journals.cambridge.org/action/displayJournal?jid=BJN
Type: article
URI: http://hdl.handle.net/2115/44113
Appears in Collections:創成研究機構 (Creative Research Institution) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 矢島 高二

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